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Arginine para Wound Healing and Immune Recovery

B

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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Conclusão

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

Key Study Findings

Systematic Review n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None vs: Standard care or placebo Outcome: Wound healing time and wound size reduction Efeito: Wound size reduction 18.6-98.2% over 2-20 weeks None

População: Adults with pressure ulcers (15 studies)

Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None vs: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing Efeito: None None

População: Murine corneal wound model and human corneal cells

In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None vs: None Outcome: Diabetic wound healing Efeito: None None

População: Diabetic wound model

In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None vs: None Outcome: Diabetic wound healing Efeito: None None

População: Diabetic wound animal model

Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None vs: Untreated diabetic wound controls Outcome: Diabetic wound healing via angiogenesis Efeito: None None

População: Diabetic ulcer mice model

Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None vs: None Outcome: None Efeito: None None

População: Diabetes patients

Key Statistics

8

Estudos

600

Participantes

Positive

B

Nota

Referenced Papers

Advanced science (Weinheim, … 2024 15 citações
International journal of … 2022 77 citações
The Annals of … 2022 31 citações
Advances in experimental … 2021 206 citações
Journal of materials … 2021 36 citações
The Cochrane database … 2020 33 citações
Biological trace element … 2017 10 citações
Nutrition in clinical … 2016 42 citações
Nutrition in clinical … 2014 131 citações
Critical reviews in … 2012 969 citações
Current opinion in … 2008 240 citações
Plastic and reconstructive … 2006 98 citações
Nutrition in clinical … 2005 247 citações
The Journal of … 2004 181 citações
Mini reviews in … 2004 178 citações
Wound repair and … 2003 306 citações
The Surgical clinics … 2003 16 citações
Alternative medicine review … 2003
Advances in skin … 2001 10 citações
The American journal … 1994 91 citações
JPEN. Journal of … 1994 72 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
2-3 g/day
immunesupport:
6-9 g/day

Limite superior: No established UL; typically tolerated at 20 g/day

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Positive 1085
None -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Negative --
None -- Positive --

Melhor horário: Between meals

Safety & Side Effects

Efeitos Colaterais Relatados

  • Gastrointestinal discomfort (bloating, diarrhea, cramps)
  • Gout exacerbation (increased uric acid production)
  • Blood pressure changes
  • Worsening of herpes outbreaks (arginine supports viral replication)

Interações Conhecidas

  • Antihypertensive medications (additive blood pressure lowering)
  • PDE5 inhibitors like sildenafil (additive vasodilation)
  • Anticoagulants (may affect platelet function)
  • Potassium-sparing diuretics (arginine may increase potassium levels)

Ingestão máxima tolerável: No established UL; typically tolerated at 20 g/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.