Arginine 用于 伤口愈合与免疫恢复
B 证据 至少一项随机试验支持这一结论，结果基本一致。Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
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B
结论
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
Systematic Review
n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None
vs: Standard care or placebo
Outcome: Wound healing time and wound size reduction
效果: Wound size reduction 18.6-98.2% over 2-20 weeks
None
研究人群: Adults with pressure ulcers (15 studies)
Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None
vs: Wild-type mice and control HCECs
Outcome: Corneal epithelial wound healing
效果: None
None
研究人群: Murine corneal wound model and human corneal cells
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
效果: None
None
研究人群: Diabetic wound model
In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None
vs: None
Outcome: Diabetic wound healing
效果: None
None
研究人群: Diabetic wound animal model
Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None
vs: Untreated diabetic wound controls
Outcome: Diabetic wound healing via angiogenesis
效果: None
None
研究人群: Diabetic ulcer mice model
Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Diabetes patients
Key Statistics
8
研究数量
600
受试者
↑
Positive
B
等级
Referenced Papers
Journal of controlled …
2025
16 次引用
Journal of colloid …
2025
8 次引用
Investigative ophthalmology & …
2025
4 次引用
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Systematic Review
Wound repair and …
2025
2 次引用
ACS applied materials …
2024
27 次引用
Advanced science (Weinheim, …
2024
15 次引用
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
Nutrition (Burbank, Los …
2024
12 次引用
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2024
4 次引用
Molecular metabolism
2024
3 次引用
Journal of tissue …
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2 次引用
Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.
Other
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2023
237 次引用
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.
Other
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Carbohydrate polymers
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A Systematic Review of Oral Nutritional Supplement and Wound Healing.
Systematic Review
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The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.
Meta-Analysis
Nursing open
2022
9 次引用
The FEBS journal
2022
8 次引用
Advances in experimental …
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206 次引用
The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.
Meta-Analysis
Nutrients
2021
123 次引用
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2021
36 次引用
Nutricion hospitalaria
2021
20 次引用
The Cochrane database …
2020
33 次引用
International journal of …
2019
265 次引用
Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review.
Systematic Review
Advances in skin …
2019
18 次引用
Biological trace element …
2017
10 次引用
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2016
42 次引用
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2015
110 次引用
Nutrition in clinical …
2014
131 次引用
Critical reviews in …
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969 次引用
Current opinion in …
2009
66 次引用
Current opinion in …
2008
240 次引用
Nutrition and wound healing.
Review
Plastic and reconstructive …
2006
98 次引用
Nutrition in clinical …
2005
247 次引用
Arginine and cancer.
Review
The Journal of …
2004
181 次引用
Mini reviews in …
2004
178 次引用
Wound repair and …
2003
306 次引用
Nutrition and wound healing.
Review
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2003
16 次引用
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2003
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Nutrition and wound healing.
Review
JPEN. Journal of …
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72 次引用
The American journal …
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135 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
上限： No established UL; typically tolerated at 20 g/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
最佳服用时间： Between meals
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
已知相互作用
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
可耐受最高摄入量： No established UL; typically tolerated at 20 g/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Arginine help with 伤口愈合与免疫恢复?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support 伤口愈合与免疫恢复 management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for 伤口愈合与免疫恢复?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and 伤口愈合与免疫恢复?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
References
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