Arginine untuk Wound Healing and Immune Recovery
B Bukti Setidaknya satu uji coba acak mendukung hal ini, dengan hasil yang sebagian besar konsisten.Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
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B
Kesimpulan
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
Systematic Review
n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None
vs: Standard care or placebo
Outcome: Wound healing time and wound size reduction
Efek: Wound size reduction 18.6-98.2% over 2-20 weeks
None
Populasi: Adults with pressure ulcers (15 studies)
Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None
vs: Wild-type mice and control HCECs
Outcome: Corneal epithelial wound healing
Efek: None
None
Populasi: Murine corneal wound model and human corneal cells
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
Efek: None
None
Populasi: Diabetic wound model
In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None
vs: None
Outcome: Diabetic wound healing
Efek: None
None
Populasi: Diabetic wound animal model
Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None
vs: Untreated diabetic wound controls
Outcome: Diabetic wound healing via angiogenesis
Efek: None
None
Populasi: Diabetic ulcer mice model
Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Diabetes patients
Key Statistics
8
Studi
600
Peserta
↑
Positive
B
Peringkat
Referenced Papers
Journal of controlled …
2025
16 sitasi
Journal of colloid …
2025
8 sitasi
Investigative ophthalmology & …
2025
4 sitasi
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Systematic Review
Wound repair and …
2025
2 sitasi
ACS applied materials …
2024
27 sitasi
Advanced science (Weinheim, …
2024
15 sitasi
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
Nutrition (Burbank, Los …
2024
12 sitasi
ACS applied bio …
2024
4 sitasi
Molecular metabolism
2024
3 sitasi
Journal of tissue …
2024
2 sitasi
Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.
Other
ACS nano
2023
237 sitasi
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.
Other
Nature communications
2023
120 sitasi
Carbohydrate polymers
2023
86 sitasi
International journal of …
2023
76 sitasi
Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair.
Other
Carbohydrate polymers
2023
32 sitasi
International journal of …
2023
31 sitasi
International journal of …
2023
27 sitasi
Biomedical materials (Bristol, …
2023
15 sitasi
International journal of …
2023
11 sitasi
International journal of …
2022
77 sitasi
A Systematic Review of Oral Nutritional Supplement and Wound Healing.
Systematic Review
The Annals of …
2022
31 sitasi
Journal of cosmetic …
2022
10 sitasi
The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.
Meta-Analysis
Nursing open
2022
9 sitasi
The FEBS journal
2022
8 sitasi
Advances in experimental …
2021
206 sitasi
The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.
Meta-Analysis
Nutrients
2021
123 sitasi
Journal of materials …
2021
36 sitasi
Nutricion hospitalaria
2021
20 sitasi
The Cochrane database …
2020
33 sitasi
International journal of …
2019
265 sitasi
Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review.
Systematic Review
Advances in skin …
2019
18 sitasi
Biological trace element …
2017
10 sitasi
Nutrition in clinical …
2016
42 sitasi
Annals of internal …
2015
110 sitasi
Nutrition in clinical …
2014
131 sitasi
Critical reviews in …
2012
969 sitasi
Current opinion in …
2009
66 sitasi
Current opinion in …
2008
240 sitasi
Nutrition and wound healing.
Review
Plastic and reconstructive …
2006
98 sitasi
Nutrition in clinical …
2005
247 sitasi
Arginine and cancer.
Review
The Journal of …
2004
181 sitasi
Mini reviews in …
2004
178 sitasi
Wound repair and …
2003
306 sitasi
Nutrition and wound healing.
Review
The Surgical clinics …
2003
16 sitasi
Alternative medicine review …
2003
Advances in skin …
2001
10 sitasi
The American journal …
1994
91 sitasi
Nutrition and wound healing.
Review
JPEN. Journal of …
1994
72 sitasi
The American journal …
1983
135 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
Batas atas: No established UL; typically tolerated at 20 g/day
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
Waktu terbaik diminum: Between meals
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
Interaksi yang Diketahui
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
Asupan atas yang dapat ditoleransi: No established UL; typically tolerated at 20 g/day
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
References
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