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Arginine untuk Wound Healing and Immune Recovery

B

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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Kesimpulan

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

Key Study Findings

Systematic Review n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None vs: Standard care or placebo Outcome: Wound healing time and wound size reduction Efek: Wound size reduction 18.6-98.2% over 2-20 weeks None

Populasi: Adults with pressure ulcers (15 studies)

Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None vs: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing Efek: None None

Populasi: Murine corneal wound model and human corneal cells

In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None vs: None Outcome: Diabetic wound healing Efek: None None

Populasi: Diabetic wound model

In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None vs: None Outcome: Diabetic wound healing Efek: None None

Populasi: Diabetic wound animal model

Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None vs: Untreated diabetic wound controls Outcome: Diabetic wound healing via angiogenesis Efek: None None

Populasi: Diabetic ulcer mice model

Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None vs: None Outcome: None Efek: None None

Populasi: Diabetes patients

Key Statistics

8

Studi

600

Peserta

Positive

B

Peringkat

Referenced Papers

Advanced science (Weinheim, … 2024 15 sitasi
International journal of … 2022 77 sitasi
The Annals of … 2022 31 sitasi
Advances in experimental … 2021 206 sitasi
Journal of materials … 2021 36 sitasi
The Cochrane database … 2020 33 sitasi
Biological trace element … 2017 10 sitasi
Nutrition in clinical … 2016 42 sitasi
Nutrition in clinical … 2014 131 sitasi
Critical reviews in … 2012 969 sitasi
Current opinion in … 2008 240 sitasi
Plastic and reconstructive … 2006 98 sitasi
Nutrition in clinical … 2005 247 sitasi
The Journal of … 2004 181 sitasi
Mini reviews in … 2004 178 sitasi
Wound repair and … 2003 306 sitasi
The Surgical clinics … 2003 16 sitasi
Alternative medicine review … 2003
Advances in skin … 2001 10 sitasi
The American journal … 1994 91 sitasi
JPEN. Journal of … 1994 72 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:
2-3 g/day
immunesupport:
6-9 g/day

Batas atas: No established UL; typically tolerated at 20 g/day

Dosis yang Diteliti dalam Penelitian

Dosis Durasi Efek N
None -- Positive 1085
None -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Negative --
None -- Positive --

Waktu terbaik diminum: Between meals

Safety & Side Effects

Efek Samping yang Dilaporkan

  • Gastrointestinal discomfort (bloating, diarrhea, cramps)
  • Gout exacerbation (increased uric acid production)
  • Blood pressure changes
  • Worsening of herpes outbreaks (arginine supports viral replication)

Interaksi yang Diketahui

  • Antihypertensive medications (additive blood pressure lowering)
  • PDE5 inhibitors like sildenafil (additive vasodilation)
  • Anticoagulants (may affect platelet function)
  • Potassium-sparing diuretics (arginine may increase potassium levels)

Asupan atas yang dapat ditoleransi: No established UL; typically tolerated at 20 g/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

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