Arginine cho Wound Healing and Immune Recovery

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Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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Kết luận

Key Study Findings

Systematic Review n=1085

The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.

Dose: None so với: Standard care or placebo Outcome: Wound healing time and wound size reduction Hiệu quả: Wound size reduction 18.6-98.2% over 2-20 weeks None

Đối tượng nghiên cứu: Adults with pressure ulcers (15 studies)

Other

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.

Dose: None so với: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing Hiệu quả: None None

Đối tượng nghiên cứu: Murine corneal wound model and human corneal cells

In Vitro

Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.

Dose: None so với: None Outcome: Diabetic wound healing Hiệu quả: None None

Đối tượng nghiên cứu: Diabetic wound model

In Vitro

Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.

Dose: None so với: None Outcome: Diabetic wound healing Hiệu quả: None None

Đối tượng nghiên cứu: Diabetic wound animal model

Other

Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.

Dose: None so với: Untreated diabetic wound controls Outcome: Diabetic wound healing via angiogenesis Hiệu quả: None None

Đối tượng nghiên cứu: Diabetic ulcer mice model

Other

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Diabetes patients

Key Statistics

Nghiên cứu

600

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis. Other

Journal of controlled … 2025 16 trích dẫn

Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. Other

Journal of colloid … 2025 8 trích dẫn

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3. Other

Investigative ophthalmology & … 2025 4 trích dẫn

The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review. Systematic Review

Wound repair and … 2025 2 trích dẫn

Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing. Other

ACS applied materials … 2024 27 trích dẫn

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5. Other

Advanced science (Weinheim, … 2024 15 trích dẫn

Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Systematic Review

Nutrition (Burbank, Los … 2024 12 trích dẫn

l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats. Other

ACS applied bio … 2024 4 trích dẫn

Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes. Other

Molecular metabolism 2024 3 trích dẫn

Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol. Other

Journal of tissue … 2024 2 trích dẫn

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing. Other

ACS nano 2023 237 trích dẫn

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. Other

Nature communications 2023 120 trích dẫn

Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. Other

Carbohydrate polymers 2023 86 trích dẫn

Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. Other

International journal of … 2023 76 trích dẫn

Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair. Other

Carbohydrate polymers 2023 32 trích dẫn

A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing. Other

International journal of … 2023 31 trích dẫn

Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin. Other

International journal of … 2023 27 trích dẫn

Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration. Other

Biomedical materials (Bristol, … 2023 15 trích dẫn

Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics. Other

International journal of … 2023 11 trích dẫn

Keratin-based wound dressings: From waste to wealth. Review

International journal of … 2022 77 trích dẫn

A Systematic Review of Oral Nutritional Supplement and Wound Healing. Systematic Review

The Annals of … 2022 31 trích dẫn

Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. Other

Journal of cosmetic … 2022 10 trích dẫn

The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis. Meta-Analysis

Nursing open 2022 9 trích dẫn

Arginine methylation in the epithelial-to-mesenchymal transition. Review

The FEBS journal 2022 8 trích dẫn

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 trích dẫn

The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Meta-Analysis

Nutrients 2021 123 trích dẫn

Advances and impact of arginine-based materials in wound healing. Review

Journal of materials … 2021 36 trích dẫn

[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. Other

Nutricion hospitalaria 2021 20 trích dẫn

Nutritional interventions for treating foot ulcers in people with diabetes. Meta-Analysis

The Cochrane database … 2020 33 trích dẫn

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Review

International journal of … 2019 265 trích dẫn

Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review. Systematic Review

Advances in skin … 2019 18 trích dẫn

Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing. Other

Biological trace element … 2017 10 trích dẫn

When Is It Appropriate to Use Arginine in Critical Illness? Review

Nutrition in clinical … 2016 42 trích dẫn

A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. RCT

Annals of internal … 2015 110 trích dẫn

Nutrition optimization prior to surgery. Review

Nutrition in clinical … 2014 131 trích dẫn

M1 and M2 Macrophages: Oracles of Health and Disease. Review

Critical reviews in … 2012 969 trích dẫn

Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Review

Current opinion in … 2009 66 trích dẫn

Assessment and nutritional aspects of wound healing. Review

Current opinion in … 2008 240 trích dẫn

Nutrition and wound healing. Review

Plastic and reconstructive … 2006 98 trích dẫn

Arginine supplementation and wound healing. Review

Nutrition in clinical … 2005 247 trích dẫn

Arginine and cancer. Review

The Journal of … 2004 181 trích dẫn

Cellular and physiological effects of arginine. Review

Mini reviews in … 2004 178 trích dẫn

Arginine physiology and its implication for wound healing. Review

Wound repair and … 2003 306 trích dẫn

Nutrition and wound healing. Review

The Surgical clinics … 2003 16 trích dẫn

Nutritional support for wound healing. Review

Alternative medicine review … 2003

Arginine and wound healing. Other

Advances in skin … 2001 10 trích dẫn

Cytokines and L-arginine in renal injury and repair. Review

The American journal … 1994 91 trích dẫn

Nutrition and wound healing. Review

JPEN. Journal of … 1994 72 trích dẫn

Arginine enhances wound healing and lymphocyte immune responses in humans. RCT

Surgery 1990

Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. Other

The American journal … 1983 135 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 2-3 g/day
immunesupport:: 6-9 g/day

Giới hạn trên: No established UL; typically tolerated at 20 g/day

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	1085
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Negative	--
None	--	Positive	--

Thời điểm dùng tốt nhất: Between meals

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
⚠ Gout exacerbation (increased uric acid production)
⚠ Blood pressure changes
⚠ Worsening of herpes outbreaks (arginine supports viral replication)

Tương tác đã biết

● Antihypertensive medications (additive blood pressure lowering)
● PDE5 inhibitors like sildenafil (additive vasodilation)
● Anticoagulants (may affect platelet function)
● Potassium-sparing diuretics (arginine may increase potassium levels)

Mức hấp thụ tối đa cho phép: No established UL; typically tolerated at 20 g/day

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?

Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).

How much Arginine should I take for Wound Healing and Immune Recovery?

Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Arginine?

Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Arginine and Wound Healing and Immune Recovery?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Đánh giá nhanh

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (2)Meta (3)Other (3)

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Tìm hiểu thêm

References

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[2] Jialiang Pan et al.. J Colloid Interface Sci. 2025. Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. doi:10.1016/j.jcis.2025.138423 PubMed
[3] Qiongjie Cao et al.. Invest Ophthalmol Vis Sci. 2025. PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3. doi:10.1167/iovs.66.1.22 PubMed
[4] Tim Torsy et al.. Wound Repair Regen. 2025. The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review. doi:10.1111/wrr.70077 PubMed
[5] Yan Yang et al.. ACS Appl Mater Interfaces. 2024. Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing. doi:10.1021/acsami.3c13072 PubMed
[6] Qian Zhang et al.. Adv Sci (Weinh). 2024. Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5. doi:10.1002/advs.202405987 PubMed
[7] Allan Carlos Soares do Espírito Santo et al.. Nutrition. 2024. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. doi:10.1016/j.nut.2024.112449 PubMed
[8] Iniyan Saravanakumar et al.. ACS Appl Bio Mater. 2024. l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats. doi:10.1021/acsabm.4c00729 PubMed
[9] Ammar A Abdelrahman et al.. Mol Metab. 2024. Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes. doi:10.1016/j.molmet.2024.102020 PubMed
[10] Tim Torsy et al.. J Tissue Viability. 2024. Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol. doi:10.1016/j.jtv.2024.03.001 PubMed
[11] Limin Shang et al.. ACS Nano. 2023. Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing. doi:10.1021/acsnano.3c04134 PubMed
[12] Jinjian Huang et al.. Nat Commun. 2023. A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. doi:10.1038/s41467-023-43364-2 PubMed
[13] Ganzhe Mao et al.. Carbohydr Polym. 2023. Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. doi:10.1016/j.carbpol.2023.120757 PubMed
[14] Shuofei Yang et al.. Int J Biol Sci. 2023. Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. doi:10.7150/ijbs.78046 PubMed
[15] Asghar Eskandarinia et al.. Carbohydr Polym. 2023. Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair. doi:10.1016/j.carbpol.2023.121171 PubMed
[16] Lifeng Zhang et al.. Int J Biol Macromol. 2023. A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing. doi:10.1016/j.ijbiomac.2023.126014 PubMed
[17] Muhammad Hasnain et al.. Int J Biol Macromol. 2023. Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin. doi:10.1016/j.ijbiomac.2023.126697 PubMed
[18] Hillary Mndlovu et al.. Biomed Mater. 2023. Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration. doi:10.1088/1748-605X/acce88 PubMed
[19] Shiqi Ye et al.. Int J Biol Sci. 2023. Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics. doi:10.7150/ijbs.80323 PubMed
[20] Wenjin Ye et al.. Int J Biol Macromol. 2022. Keratin-based wound dressings: From waste to wealth. doi:10.1016/j.ijbiomac.2022.04.216 PubMed
[21] Ghazal S Daher et al.. Ann Otol Rhinol Laryngol. 2022. A Systematic Review of Oral Nutritional Supplement and Wound Healing. doi:10.1177/00034894211069437 PubMed
[22] Koo Chul Kwon et al.. J Cosmet Dermatol. 2022. Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. doi:10.1111/jocd.14957 PubMed
[23] Sahar Cheshmeh et al.. Nurs Open. 2022. The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis. doi:10.1002/nop2.974 PubMed
[24] Jian Qin et al.. FEBS J. 2022. Arginine methylation in the epithelial-to-mesenchymal transition. doi:10.1111/febs.16152 PubMed
[25] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
[26] Elena Arribas-López et al.. Nutrients. 2021. The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. doi:10.3390/nu13082498 PubMed
[27] Yang Zhou et al.. J Mater Chem B. 2021. Advances and impact of arginine-based materials in wound healing. doi:10.1039/d1tb00958c PubMed
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[29] Zena Eh Moore et al.. Cochrane Database Syst Rev. 2020. Nutritional interventions for treating foot ulcers in people with diabetes. doi:10.1002/14651858.CD011378.pub2 PubMed
[30] Martina Barchitta et al.. Int J Mol Sci. 2019. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. doi:10.3390/ijms20051119 PubMed
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[32] Ali Said Durmus et al.. Biol Trace Elem Res. 2017. Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing. doi:10.1007/s12011-016-0857-2 PubMed
[33] Jayshil J Patel et al.. Nutr Clin Pract. 2016. When Is It Appropriate to Use Arginine in Critical Illness? doi:10.1177/0884533616652576 PubMed
[34] Emanuele Cereda et al.. Ann Intern Med. 2015. A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. doi:10.7326/M14-0696 PubMed
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[38] Antonio C L Campos et al.. Curr Opin Clin Nutr Metab Care. 2008. Assessment and nutritional aspects of wound healing. doi:10.1097/MCO.0b013e3282fbd35a PubMed
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