Arginine для Wound Healing and Immune Recovery
B Доказательства По меньшей мере одно рандомизированное исследование подтверждает это, с в целом согласованными результатами.Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
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B
Итог
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
Systematic Review
n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None
или: Standard care or placebo
Outcome: Wound healing time and wound size reduction
Эффект: Wound size reduction 18.6-98.2% over 2-20 weeks
None
Популяция: Adults with pressure ulcers (15 studies)
Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None
или: Wild-type mice and control HCECs
Outcome: Corneal epithelial wound healing
Эффект: None
None
Популяция: Murine corneal wound model and human corneal cells
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
или: None
Outcome: Diabetic wound healing
Эффект: None
None
Популяция: Diabetic wound model
In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None
или: None
Outcome: Diabetic wound healing
Эффект: None
None
Популяция: Diabetic wound animal model
Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None
или: Untreated diabetic wound controls
Outcome: Diabetic wound healing via angiogenesis
Эффект: None
None
Популяция: Diabetic ulcer mice model
Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: Diabetes patients
Key Statistics
8
Исследования
600
Участники
↑
Positive
B
Оценка
Referenced Papers
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2025
16 цитирований
Journal of colloid …
2025
8 цитирований
Investigative ophthalmology & …
2025
4 цитирований
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Systematic Review
Wound repair and …
2025
2 цитирований
ACS applied materials …
2024
27 цитирований
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15 цитирований
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.
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The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.
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Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review.
Systematic Review
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
Верхний предел: No established UL; typically tolerated at 20 g/day
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
Лучшее время приёма: Between meals
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
Известные взаимодействия
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
Допустимый верхний уровень потребления: No established UL; typically tolerated at 20 g/day
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
References
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