Arginine के लिए Wound Healing and Immune Recovery

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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निष्कर्ष

Key Study Findings

Systematic Review n=1085

The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.

Dose: None बनाम: Standard care or placebo Outcome: Wound healing time and wound size reduction प्रभाव: Wound size reduction 18.6-98.2% over 2-20 weeks None

जनसंख्या: Adults with pressure ulcers (15 studies)

Other

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.

Dose: None बनाम: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing प्रभाव: None None

जनसंख्या: Murine corneal wound model and human corneal cells

In Vitro

Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.

Dose: None बनाम: None Outcome: Diabetic wound healing प्रभाव: None None

जनसंख्या: Diabetic wound model

In Vitro

Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.

Dose: None बनाम: None Outcome: Diabetic wound healing प्रभाव: None None

जनसंख्या: Diabetic wound animal model

Other

Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.

Dose: None बनाम: Untreated diabetic wound controls Outcome: Diabetic wound healing via angiogenesis प्रभाव: None None

जनसंख्या: Diabetic ulcer mice model

Other

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: Diabetes patients

Key Statistics

अध्ययन

600

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis. Other

Journal of controlled … 2025 16 उद्धरण

Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. Other

Journal of colloid … 2025 8 उद्धरण

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3. Other

Investigative ophthalmology & … 2025 4 उद्धरण

The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review. Systematic Review

Wound repair and … 2025 2 उद्धरण

Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing. Other

ACS applied materials … 2024 27 उद्धरण

Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5. Other

Advanced science (Weinheim, … 2024 15 उद्धरण

Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Systematic Review

Nutrition (Burbank, Los … 2024 12 उद्धरण

l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats. Other

ACS applied bio … 2024 4 उद्धरण

Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes. Other

Molecular metabolism 2024 3 उद्धरण

Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol. Other

Journal of tissue … 2024 2 उद्धरण

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing. Other

ACS nano 2023 237 उद्धरण

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing. Other

Nature communications 2023 120 उद्धरण

Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. Other

Carbohydrate polymers 2023 86 उद्धरण

Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. Other

International journal of … 2023 76 उद्धरण

Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair. Other

Carbohydrate polymers 2023 32 उद्धरण

A phellinus igniarius polysaccharide/chitosan-arginine hydrogel for promoting diabetic wound healing. Other

International journal of … 2023 31 उद्धरण

Microarray needles comprised of arginine-modified chitosan/PVA hydrogel for enhanced antibacterial and wound healing potential of curcumin. Other

International journal of … 2023 27 उद्धरण

Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration. Other

Biomedical materials (Bristol, … 2023 15 उद्धरण

Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics. Other

International journal of … 2023 11 उद्धरण

Keratin-based wound dressings: From waste to wealth. Review

International journal of … 2022 77 उद्धरण

A Systematic Review of Oral Nutritional Supplement and Wound Healing. Systematic Review

The Annals of … 2022 31 उद्धरण

Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. Other

Journal of cosmetic … 2022 10 उद्धरण

The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis. Meta-Analysis

Nursing open 2022 9 उद्धरण

Arginine methylation in the epithelial-to-mesenchymal transition. Review

The FEBS journal 2022 8 उद्धरण

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 उद्धरण

The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Meta-Analysis

Nutrients 2021 123 उद्धरण

Advances and impact of arginine-based materials in wound healing. Review

Journal of materials … 2021 36 उद्धरण

[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. Other

Nutricion hospitalaria 2021 20 उद्धरण

Nutritional interventions for treating foot ulcers in people with diabetes. Meta-Analysis

The Cochrane database … 2020 33 उद्धरण

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Review

International journal of … 2019 265 उद्धरण

Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review. Systematic Review

Advances in skin … 2019 18 उद्धरण

Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing. Other

Biological trace element … 2017 10 उद्धरण

When Is It Appropriate to Use Arginine in Critical Illness? Review

Nutrition in clinical … 2016 42 उद्धरण

A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. RCT

Annals of internal … 2015 110 उद्धरण

Nutrition optimization prior to surgery. Review

Nutrition in clinical … 2014 131 उद्धरण

M1 and M2 Macrophages: Oracles of Health and Disease. Review

Critical reviews in … 2012 969 उद्धरण

Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Review

Current opinion in … 2009 66 उद्धरण

Assessment and nutritional aspects of wound healing. Review

Current opinion in … 2008 240 उद्धरण

Nutrition and wound healing. Review

Plastic and reconstructive … 2006 98 उद्धरण

Arginine supplementation and wound healing. Review

Nutrition in clinical … 2005 247 उद्धरण

Arginine and cancer. Review

The Journal of … 2004 181 उद्धरण

Cellular and physiological effects of arginine. Review

Mini reviews in … 2004 178 उद्धरण

Arginine physiology and its implication for wound healing. Review

Wound repair and … 2003 306 उद्धरण

Nutrition and wound healing. Review

The Surgical clinics … 2003 16 उद्धरण

Nutritional support for wound healing. Review

Alternative medicine review … 2003

Arginine and wound healing. Other

Advances in skin … 2001 10 उद्धरण

Cytokines and L-arginine in renal injury and repair. Review

The American journal … 1994 91 उद्धरण

Nutrition and wound healing. Review

JPEN. Journal of … 1994 72 उद्धरण

Arginine enhances wound healing and lymphocyte immune responses in humans. RCT

Surgery 1990

Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. Other

The American journal … 1983 135 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 2-3 g/day
immunesupport:: 6-9 g/day

अधिकतम सीमा: No established UL; typically tolerated at 20 g/day

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Positive	1085
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Negative	--
None	--	Positive	--

सेवन का सर्वोत्तम समय: Between meals

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
⚠ Gout exacerbation (increased uric acid production)
⚠ Blood pressure changes
⚠ Worsening of herpes outbreaks (arginine supports viral replication)

ज्ञात अंतःक्रियाएँ

● Antihypertensive medications (additive blood pressure lowering)
● PDE5 inhibitors like sildenafil (additive vasodilation)
● Anticoagulants (may affect platelet function)
● Potassium-sparing diuretics (arginine may increase potassium levels)

सहनीय अधिकतम सेवन: No established UL; typically tolerated at 20 g/day

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?

Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).

How much Arginine should I take for Wound Healing and Immune Recovery?

Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Arginine?

Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Arginine and Wound Healing and Immune Recovery?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

संक्षिप्त निष्कर्ष

Evidence Strength72%

High confidence

अध्ययन विश्लेषण

RCT (2)Meta (3)Other (3)

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इसके लिए सभी सामग्री देखें Wound Healing and Immune Recovery

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।