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Arginine für Wound Healing and Immune Recovery

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Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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Fazit

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

Key Study Findings

Systematic Review n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None vs.: Standard care or placebo Outcome: Wound healing time and wound size reduction Wirkung: Wound size reduction 18.6-98.2% over 2-20 weeks None

Population: Adults with pressure ulcers (15 studies)

Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None vs.: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing Wirkung: None None

Population: Murine corneal wound model and human corneal cells

In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None vs.: None Outcome: Diabetic wound healing Wirkung: None None

Population: Diabetic wound model

In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None vs.: None Outcome: Diabetic wound healing Wirkung: None None

Population: Diabetic wound animal model

Other
Arginine-Nanoenzyme with Timely Angiogenesis for Promoting Diabetic Wound Healing.
Dose: None vs.: Untreated diabetic wound controls Outcome: Diabetic wound healing via angiogenesis Wirkung: None None

Population: Diabetic ulcer mice model

Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: Diabetes patients

Key Statistics

8

Studien

600

Teilnehmer

Positive

B

Bewertung

Referenced Papers

Advanced science (Weinheim, … 2024 15 Zitierungen
International journal of … 2022 77 Zitierungen
The Annals of … 2022 31 Zitierungen
Advances in experimental … 2021 206 Zitierungen
Journal of materials … 2021 36 Zitierungen
The Cochrane database … 2020 33 Zitierungen
Biological trace element … 2017 10 Zitierungen
Nutrition in clinical … 2016 42 Zitierungen
Nutrition in clinical … 2014 131 Zitierungen
Critical reviews in … 2012 969 Zitierungen
Current opinion in … 2008 240 Zitierungen
Plastic and reconstructive … 2006 98 Zitierungen
Nutrition in clinical … 2005 247 Zitierungen
The Journal of … 2004 181 Zitierungen
Mini reviews in … 2004 178 Zitierungen
Wound repair and … 2003 306 Zitierungen
The Surgical clinics … 2003 16 Zitierungen
Alternative medicine review … 2003
Advances in skin … 2001 10 Zitierungen
The American journal … 1994 91 Zitierungen
JPEN. Journal of … 1994 72 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
2-3 g/day
immunesupport:
6-9 g/day

Obergrenze: No established UL; typically tolerated at 20 g/day

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Positive 1085
None -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Negative --
None -- Positive --

Beste Einnahmezeit: Between meals

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Gastrointestinal discomfort (bloating, diarrhea, cramps)
  • Gout exacerbation (increased uric acid production)
  • Blood pressure changes
  • Worsening of herpes outbreaks (arginine supports viral replication)

Bekannte Wechselwirkungen

  • Antihypertensive medications (additive blood pressure lowering)
  • PDE5 inhibitors like sildenafil (additive vasodilation)
  • Anticoagulants (may affect platelet function)
  • Potassium-sparing diuretics (arginine may increase potassium levels)

Tolerierbare Höchstaufnahmemenge: No established UL; typically tolerated at 20 g/day

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

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