Conditions

18 health conditions with evidence-based supplement research

Explore health conditions with evidence-graded supplement recommendations. Each condition page ranks ingredients by the strength of clinical research supporting them.

How We Grade Evidence

Each condition page ranks supplement ingredients by the strength of clinical evidence. Here is what each grade means:

Strong Evidence

Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.

Good Evidence

At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.

Some Evidence

Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.

Very Early Research

In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.

Acute Bronchitis

5% of adults annually

Persistent cough (productive or dry) Chest discomfort Fatigue +3

Allergic Rhinitis

10-30% of adults globally; 40% of children

Sneezing Runny nose Nasal congestion +4

Autoimmune Conditions

5-8% of the population; >80 recognized autoimmune diseases

Varies by condition (fatigue, joint pain, skin rashes, digestive issues) Organ-specific symptoms Flare-remission cycles

Chronic Inflammation

Estimated 50-60% of adults have at least one inflammatory biomarker elevation

Fatigue Joint stiffness Recurring infections +3

Exercise-Induced Immune Suppression

Affects endurance athletes and those in heavy training

Post-exercise URTIs Prolonged recovery Fatigue +1

Gut Immune Health

Gut dysbiosis affects an estimated 25-45% of adults

Recurrent infections Bloating Irregular bowel movements +3

Immune Aging (Immunosenescence)

Affects all individuals with aging; clinically significant after age 65

Increased infection frequency Slower wound healing Reduced vaccine effectiveness +2

Influenza

5-15% of global population annually

High fever Body aches Chills +5

Oxidative Stress

Universal physiological process; pathological levels associated with chronic disease

Fatigue Frequent illness Poor wound healing +3

Pediatric Immune Support

6-8 URTIs per year in children under 6

Frequent colds Ear infections Coughs +2

Post-Viral Fatigue

10-35% of individuals after certain viral infections; ~10% post-COVID

Persistent fatigue Brain fog Exercise intolerance +4

Recurrent Infections

~25% of primary care patients report recurrent infections

Frequent colds or flu Recurring sinusitis Repeated urinary tract infections +2

Sinusitis

31 million episodes annually in the US

Facial pain/pressure Nasal congestion Thick nasal discharge +3

Skin Immune Barrier

Compromised skin barrier affects 15-20% of adults (eczema, dermatitis)

Recurrent skin infections Eczema flares Delayed wound healing +2

Stress-Related Immune Suppression

Chronic stress affects 70-80% of working adults

Increased illness frequency Slow wound healing Fatigue +2

Upper Respiratory Tract Infections

2-4 episodes/year in adults; 6-8 in children

Nasal congestion Runny nose Sore throat +5

Vaccine Response Support

Suboptimal vaccine responses in 30-50% of elderly adults

Reduced antibody titers post-vaccination Shorter duration of vaccine protection Breakthrough infections

Wound Healing and Immune Recovery

50 million surgical procedures annually in the US require immune recovery support

Slow wound healing Post-surgical infection risk Delayed recovery +1

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.