Saccharomyces boulardii for Gut Immune Health

Meta-analyses support Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea and C. difficile infection. Its unique antibiotic resistance allows concurrent use during antibiotic therapy, supporting gut immune recovery.

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The Bottom Line

Key Study Findings

In Vitro

Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8+ …

Dose: 1 G vs: None Outcome: None Effect: None None

Population: None

Review

The role of probiotics and prebiotics in inducing gut immunity.

Dose: None vs: None Outcome: Gut immune system modulation Effect: None None

Population: Preclinical and clinical subjects

Key Statistics

Studies

3000

Participants

↑

Positive

Grade

Referenced Papers

Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8+ T cells ex vivo. Other

Applied microbiology and … 2019 25 citations

The role of probiotics and prebiotics in inducing gut immunity. Review

Frontiers in immunology 2013 263 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

acute:: 250 mg 2x/day
general:: 250-500 mg/day (5-10 billion CFU)

Upper limit: No established UL

Dosages Studied in Research

Dosage	Duration	Effect	N
1 G	--	Mixed	--
None	--	Positive	--

Best taken: Can be taken with antibiotics (uniquely antibiotic-resistant)

Safety & Side Effects

Reported Side Effects

⚠ Mild bloating and gas
⚠ Rare: fungemia in severely immunocompromised or ICU patients with central lines
⚠ Constipation (rare)

Known Interactions

● Antifungal medications (will kill S. boulardii; do not combine)
● Uniquely safe to use with antibiotics (inherent antibiotic resistance)

Tolerable upper intake: No established UL

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Saccharomyces boulardii help with Gut Immune Health?

Based on 15 studies with 3,000 participants, there is moderate evidence from clinical studies that Saccharomyces boulardii may support Gut Immune Health management. Our evidence grade is B (Good Evidence).

How much Saccharomyces boulardii should I take for Gut Immune Health?

Studies have used various dosages. A commonly studied range is 250 mg 2x/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Saccharomyces boulardii?

Reported side effects may include Mild bloating and gas, Rare: fungemia in severely immunocompromised or ICU patients with central lines, Constipation (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Saccharomyces boulardii and Gut Immune Health?

We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 3,000 total participants. The overall direction of effect is positive.

Related Evidence

Other ingredients for Gut Immune Health

Lactobacillus rhamnosus GG B

Quick Verdict

Evidence Strength72%

High confidence

Study Breakdown

RCT (0)Meta (0)Other (15)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.