What is the recommended dosage for Arginine?

General: 2-3 g/day; Immune Support: 6-9 g/day

What are the side effects of Arginine?

Potential side effects include: Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication).

What is arginine and how does it relate to immune function?

L-arginine is a semi-essential amino acid that serves as a precursor to nitric oxide, which plays a role in immune cell signaling. Research suggests arginine may support T-cell function and wound healing, particularly in individuals with depleted levels.

What dosage of arginine has been studied for immune support?

Clinical studies have used L-arginine doses ranging from 6 to 30 g per day, depending on the condition studied. For immune-related outcomes, doses of 6–12 g per day are more commonly reported in surgical and critically ill populations.

What are the potential side effects of arginine supplementation?

Common side effects include gastrointestinal discomfort, bloating, and diarrhea at higher doses. Arginine may interact with blood pressure medications and nitrates. Individuals with herpes simplex should consult a doctor, as arginine may promote viral replication.

Arginine

amino_acid

Also known as: L-Arginine

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About

Arginine is the primary precursor of nitric oxide (NO), which is essential for macrophage cytotoxicity against pathogens. It supports T-cell proliferation, lymphocyte function, and wound healing through polyamine and proline synthesis. Clinical evidence is strongest in post-surgical and critically ill populations.

How It Works

Primary precursor of nitric oxide (NO) via nitric oxide synthase, essential for macrophage cytotoxicity against pathogens; supports T-cell proliferation and wound healing through polyamine and proline synthesis.

Evidence For Conditions

Condition	Grade	Studies	Participants
Wound Healing and Immune Recovery	B	8	600	View →

Side Effects

Gastrointestinal discomfort (bloating, diarrhea, cramps)
Gout exacerbation (increased uric acid production)
Blood pressure changes
Worsening of herpes outbreaks (arginine supports viral replication)

Drug & Supplement Interactions

Antihypertensive medications (additive blood pressure lowering)
PDE5 inhibitors like sildenafil (additive vasodilation)
Anticoagulants (may affect platelet function)
Potassium-sparing diuretics (arginine may increase potassium levels)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Glutamine N-Acetylcysteine

Quick Facts

Dosage: General: 2-3 g/day; Immune_Support: 6-9 g/day
Forms: powder capsule tablet
Natural Sources: Turkey, Pork, Chicken, Pumpkin seeds, Soybeans, Peanuts
Upper Limit: No established UL; typically tolerated at 20 g/day
Best Time: Between meals

Evidence Summary

Wound Healing and Immune Recovery B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.