What is the recommended dosage for Glutamine?

General: 5-10 g/day; Immune Support: 10-20 g/day during illness or stress

What are the side effects of Glutamine?

Potential side effects include: Generally well tolerated, Bloating and gastrointestinal discomfort at high doses, Headache (rare), Contraindicated in hepatic encephalopathy.

What is glutamine and how does it relate to immune function?

Glutamine is the most abundant amino acid in the body and serves as a primary fuel source for immune cells, including lymphocytes and macrophages. During periods of physiological stress, glutamine demand may exceed the body's production capacity.

What dosage of glutamine has been studied for immune support?

Clinical trials have used L-glutamine at doses of 5–30 g per day, depending on the clinical context. For exercise-related immune suppression, doses of 5–10 g per day are common. Higher doses are used in critical care settings under medical supervision.

What are the potential side effects of glutamine supplementation?

Glutamine is generally well tolerated at doses up to 30 g per day in healthy adults. Side effects may include bloating and gastrointestinal discomfort. Individuals with liver disease, kidney disease, or seizure disorders should consult a doctor before use.

Glutamine

amino_acid

Also known as: L-Glutamine

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About

Glutamine is the most abundant amino acid utilized by immune cells at extremely high rates. It serves as primary fuel for lymphocyte proliferation and macrophage function, is critical for optimal cytokine production, and maintains gut-associated lymphoid tissue (GALT) integrity. Part of clinical immunonutrition protocols.

How It Works

Most abundant amino acid utilized by immune cells; serves as primary fuel for lymphocyte proliferation and macrophage function; critical for optimal cytokine production and maintenance of GALT integrity.

Evidence For Conditions

Condition	Grade	Studies	Participants
Exercise-Induced Immune Suppression	B	10	800	View →

Side Effects

Generally well tolerated
Bloating and gastrointestinal discomfort at high doses
Headache (rare)
Contraindicated in hepatic encephalopathy

Drug & Supplement Interactions

Lactulose (glutamine may reduce lactulose effectiveness)
Anti-seizure medications (may alter seizure threshold)
Chemotherapy agents (consult oncologist before use)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Arginine N-Acetylcysteine

Quick Facts

Dosage: General: 5-10 g/day; Immune_Support: 10-20 g/day during illness or stress
Forms: powder capsule tablet
Natural Sources: Beef, Chicken, Fish, Eggs, Dairy, Beans, Cabbage
Upper Limit: 40 g/day (supplemental)
Best Time: Between meals or post-exercise; can be divided into multiple doses

Evidence Summary

Exercise-Induced Immune Suppression B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.