Glutamine for Exercise-Induced Immune Suppression

Glutamine is part of clinical immunonutrition protocols. Depletion during intense exercise is associated with increased infection risk. Supplementation may help support gut barrier integrity and immune cell metabolism during heavy training periods.

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The Bottom Line

Key Study Findings

Review

Performance and altitude: Ways that nutrition can help.

Dose: None vs: None Outcome: None Effect: None None

Population: None

Review

Importance of exercise immunology in health promotion.

Dose: None vs: None Outcome: immune function Effect: None None

Population: heart failure patients

Randomized Controlled Trial 104.0 weeks

Selenium and glutamine supplements: where are we heading? A critical care perspective.

Dose: None vs: None Outcome: mortality Effect: None None

Population: None

Review

Exercise immunology: nutritional countermeasures.

Dose: Vitamin C, E, glutamine, zinc vs: None Outcome: Immune function during exercise Effect: None None

Population: Athletes

Review

Exercise immunology: future directions for research related to athletes, nutrition, and the elderly.

Dose: None vs: placebo Outcome: body weight Effect: None None

Population: athletes

Observational Study 2.0 weeks

Is infection risk linked to exercise workload?

Dose: None vs: None Outcome: immune function Effect: None None

Population: athletes

Key Statistics

Studies

800

Participants

↑

Positive

Grade

Referenced Papers

Performance and altitude: Ways that nutrition can help. Review

Nutrition (Burbank, Los … 2019 11 citations

Importance of exercise immunology in health promotion. Review

Amino acids 2011 45 citations

Selenium and glutamine supplements: where are we heading? A critical care perspective. Review

Current opinion in … 2010 18 citations

Exercise immunology: nutritional countermeasures. Review

Canadian journal of … 2001 72 citations

Is infection risk linked to exercise workload? Review

Medicine and science … 2000 262 citations

Exercise immunology: future directions for research related to athletes, nutrition, and the elderly. Review

International journal of … 2000 57 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:: 5-10 g/day
immunesupport:: 10-20 g/day during illness or stress

Upper limit: 40 g/day (supplemental)

Dosages Studied in Research

Dosage	Duration	Effect	N
None	--	Mixed	--
None	--	Mixed	--
None	104.0 weeks	Positive	--
Vitamin C, E, glutamine, zinc	--	Positive	--
None	--	Mixed	--
None	2.0 weeks	Mixed	--

Best taken: Between meals or post-exercise; can be divided into multiple doses

Safety & Side Effects

Reported Side Effects

⚠ Generally well tolerated
⚠ Bloating and gastrointestinal discomfort at high doses
⚠ Headache (rare)
⚠ Contraindicated in hepatic encephalopathy

Known Interactions

● Lactulose (glutamine may reduce lactulose effectiveness)
● Anti-seizure medications (may alter seizure threshold)
● Chemotherapy agents (consult oncologist before use)

Tolerable upper intake: 40 g/day (supplemental)

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Glutamine help with Exercise-Induced Immune Suppression?

Based on 10 studies with 800 participants, there is moderate evidence from clinical studies that Glutamine may support Exercise-Induced Immune Suppression management. Our evidence grade is B (Good Evidence).

How much Glutamine should I take for Exercise-Induced Immune Suppression?

Studies have used various dosages. A commonly studied range is 5-10 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Glutamine?

Reported side effects may include Generally well tolerated, Bloating and gastrointestinal discomfort at high doses, Headache (rare), Contraindicated in hepatic encephalopathy. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Glutamine and Exercise-Induced Immune Suppression?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.

Related Evidence

Other ingredients for Exercise-Induced Immune Suppression

Vitamin C B

Quick Verdict

Evidence Strength72%

High confidence

Study Breakdown

RCT (0)Meta (0)Other (10)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.