What is the recommended dosage for Selenium?

General: 55 mcg/day; Immune Support: 100-200 mcg/day

What are the side effects of Selenium?

Potential side effects include: Selenosis at chronic high doses (hair loss, nail brittleness, garlic breath odor), Nausea and diarrhea, Fatigue and irritability, Nerve damage (peripheral neuropathy) at very high chronic doses.

What is selenium and how does it support the immune system?

Selenium is an essential trace mineral incorporated into selenoproteins that regulate immune cell function, antioxidant defense, and thyroid hormone metabolism. Selenium deficiency is associated with impaired immune responses and increased susceptibility to viral infections.

What dosage of selenium has been studied for immune health?

Clinical studies have used selenium at doses of 50–200 mcg per day, with 100–200 mcg being the most common range for immune outcomes. The Tolerable Upper Intake Level is 400 mcg per day, and exceeding this can cause toxicity.

What are the potential side effects of selenium supplementation?

Chronic intake above 400 mcg per day can cause selenosis, characterized by hair loss, nail brittleness, garlic breath, fatigue, and gastrointestinal symptoms. Selenium has a narrow therapeutic window, and supplementation should be based on dietary intake assessment.

Selenium

mineral

Also known as: Selenomethionine, Sodium Selenite, Selenium Yeast

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About

Selenium is an essential component of selenoproteins (glutathione peroxidases, thioredoxin reductases) that regulate oxidative stress and redox signaling in immune cells. It supports optimal innate and adaptive immune responses and thyroid function. Adequate selenium status is associated with enhanced NK cell activity and improved vaccine response.

How It Works

Essential component of selenoproteins (glutathione peroxidases, thioredoxin reductases) that regulate oxidative stress and redox signaling in immune cells; supports optimal innate and adaptive immune responses.

Evidence For Conditions

Condition	Grade	Studies	Participants
Vaccine Response Support	C	5	400	View →

Side Effects

Selenosis at chronic high doses (hair loss, nail brittleness, garlic breath odor)
Nausea and diarrhea
Fatigue and irritability
Nerve damage (peripheral neuropathy) at very high chronic doses

Drug & Supplement Interactions

Cisplatin and other chemotherapy agents (selenium may modify effects)
Statins (selenium may affect cholesterol metabolism)
Birth control pills (may lower selenium levels)
Gold salts (mutual reduction of effectiveness)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Iron Zinc

Quick Facts

Dosage: General: 55 mcg/day; Immune_Support: 100-200 mcg/day
Forms: capsule tablet
Natural Sources: Brazil nuts, Seafood, Organ meats, Whole grains, Eggs
Upper Limit: 400 mcg/day
Best Time: With meals

Evidence Summary

Vaccine Response Support C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.