[Experimental study of spirulina platensis in treating allergic rhinitis in rats].
Study Design
- Study Type
- In Vitro
- Population
- Ovalbumin-sensitized rats (allergic rhinitis model)
- Intervention
- [Experimental study of spirulina platensis in treating allergic rhinitis in rats]. Spirulina platensis
- Comparator
- Negative control; positive control
- Primary Outcome
- Nasal mucosa inflammation, serum histamine, IgE
- Effect Direction
- Positive
- Risk of Bias
- Unclear
Abstract
OBJECTIVE: To determine the therapeutic effect of spirulina platensis in allergic rhinitis (AR). METHODS: Ovalbumin sensitized white rats used as AR animals were treated with spirulina platensis (SPP). At the end of the treatment, the differences in the behavior science were observed; the changes in the nasal mucosa and mast cell degranulation were studied pathologically; and the levels of serum histamine and total immunoglobulin (Ig) E were determined by enzyme-linked immune sorbent assay. RESULTS: The behavior science score of the SPP treatment group was lower than that of the negative control group (P < 0.01 ) ; inflammatory reaction of nasal mucosa in the SPP treatment group were remarkably relieved; the number of nasal mucosa mastocyte and mast cell degranulation in the SPP treatment group were lower than that of the negative control group (P <0.01 ). The levels of serum histamine and total IgE in the SPP treatment group were lower than that of the negative control group (P <0.01 ). It had no significant difference in the positive control group and the SPP treatment group and the blank control group (P > 0.05 ). CONCLUSION: Spirulina platensis can prevent and treat AR in rats, which implies the possibility of using spirulina platensis for AR patients in the future.
Used In Evidence Reviews
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