Alleviation of autoimmune disease by dietary lipids containing omega-3 fatty acids.
Study Design
- Study Type
- Review
- Population
- animal model
- Intervention
- Alleviation of autoimmune disease by dietary lipids containing omega-3 fatty acids.
- Primary Outcome
- lipid levels
- Effect Direction
- Positive
- Risk of Bias
- Unclear
Abstract
Dietary marine lipids that are enriched in omega-3, or n-3, fatty acids reduce the severity of autoimmune glomerulonephritis in several inbred murine strains. The protective effect of dietary n-3 fatty acids is also seen with a rat model of immune-complex induced vasculopathy, but no protective effects were seen with autoimmune vasculitis in the MRL/lpr mouse or with type II collagen-induced arthritis in rats. Dietary n-3 fatty acids are potential therapeutic agents for the treatment of autoimmune diseases, but careful clinical trials with the purified forms of n-3 fatty acids are needed to determine the usefulness of this intervention.
TL;DR
Dietary marine lipids that are enriched in omega-3, or n, fatty acids reduce the severity of autoimmune glomerulonephritis in several inbred murine strains and are potential therapeutic agents for the treatment of autoimmune diseases.
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