[Vitamin D and autoimmunity].
Study Design
- Study Type
- Review
- Population
- Patients with autoimmune diseases
- Intervention
- [Vitamin D and autoimmunity].
- Primary Outcome
- Autoimmune disease prevention and treatment
- Effect Direction
- Positive
- Risk of Bias
- Unclear
Abstract
Vitamin D acts at several levels in the immune systems to maintain immune tolerance. Vitamin D deficiency is a plausible environmental risk factor for autoimmune disease. Basic, genetic and epidemiological studies indicate a potential role of vitamin D in the prevention and the treatment of autoimmune diseases. Most of the epidemiological studies are cross-sectional, so that they are insufficient to establish a direct link between vitamin D deficiency and both disease risk and disease activity. Randomized, controlled trials are necessary.
TL;DR
Basic, genetic and epidemiological studies indicate a potential role of vitamin D in the prevention and the treatment of autoimmune diseases, but they are insufficient to establish a direct link between vitamin D deficiency and both disease risk and disease activity.
Used In Evidence Reviews
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