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Figure 2. Therapeutic strategies targeting lysosomal dysfunction in cardiovascular diseases. This schematic illustrates lysosomal dysfunction as a central contributor to CVDs and highlights emerging therapeutic strategies targeting these pathways. Lysosom
Figure 2. Figure 2. Therapeutic strategies targeting lysosomal dysfunction in cardiovascular diseases. This schematic illustrates lysosomal dysfunction as a central contributor to CVDs and highlights emerging therapeutic strategies targeting these pathways. Lysosomal stress disrupts autophagic flux, promotes lipid accumulation, activates the NLRP3 inflammasome, and triggers ferroptosis, collectively exacerbating inflammation and oxidative stress.

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Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.

Biomedicines (2025)

PMID: 40426881

DOI: 10.3390/biomedicines13051053

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![Figure 2: Figure 2. Therapeutic strategies targeting lysosomal dysfunction in cardiovascular diseases. This schematic illustrates lysosomal dysfunction as a central contributor to CVDs and highlights emerging therapeutic strategies targeting these pathways. Lysosom](https://pdfs.citedhealth.com/figures/40426881/180.png)

> Source: Toshiki Otoda et al. "Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovasc." *Biomedicines*, 2025. PMID: [40426881](https://pubmed.ncbi.nlm.nih.gov/40426881/)
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  <img src="https://pdfs.citedhealth.com/figures/40426881/180.png" alt="Figure 2. Therapeutic strategies targeting lysosomal dysfunction in cardiovascular diseases. This schematic illustrates lysosomal dysfunction as a central contributor to CVDs and highlights emerging therapeutic strategies targeting these pathways. Lysosom" />
  <figcaption>Figure 2. Figure 2. Therapeutic strategies targeting lysosomal dysfunction in cardiovascular diseases. This schematic illustrates lysosomal dysfunction as a central contributor to CVDs and highlights emerging therapeutic strategies targeting these pathways. Lysosom<br>  Source: Toshiki Otoda et al. "Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovasc." <em>Biomedicines</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40426881/">40426881</a></figcaption>
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