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Fig. 1 Histopathological alterations in ovarian sections of the control and the experimental groups. a control; b PCOS; c solvent; d resveratrol; e metformin and f metformin+resveratrol group. g-l higher magnification of the follicles in these groups, res
Figure 5. Fig. 1 Histopathological alterations in ovarian sections of the control and the experimental groups. a control; b PCOS; c solvent; d resveratrol; e metformin and f metformin+resveratrol group. g-l higher magnification of the follicles in these groups, respectively. Control group exhibited normal ovarian morphology whereas PCOS and solvent groups showed many cystic and atretic follicles. Treatment groups improved ovarian architecture as indicated by increasing number of corpus luteum and Graafian follicle. CF indicates cystic follicle; AF, atretic follicle; CL, corpus luteum; arrow, apoptotic granulosa cells in antrum. (A-F, 4X magnification; G-L, 40X magnification, H&E)

描述

Histopathological analysis of ovarian sections across control and experimental groups shows characteristic PCOS features including multiple cystic follicles and thickened theca cell layers. Treatment groups demonstrate partial normalization of ovarian morphology.

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SIRT1 immunoreactivity in ovarian tissue varies across experimental groups, with reduced expression in PCOS rats and partial restoration following resveratrol and metformin treatment. SIRT1 is implicated in cellular stress responses and metabolic regulation.

Figure 6

SIRT1 immunoreactivity in ovarian tissue varies across experimental groups, with reduced expression in PCOS rats and partial restoration following resveratrol and metformin treatment. SIRT1 is implicated in cellular stress responses and metabolic regulation.

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AMPK immunoreactivity analysis reveals decreased phosphorylated AMPK in PCOS ovarian tissue compared to controls. Both metformin and resveratrol treatments partially restore AMPK activation, consistent with their known metabolic signaling effects.

Figure 7

AMPK immunoreactivity analysis reveals decreased phosphorylated AMPK in PCOS ovarian tissue compared to controls. Both metformin and resveratrol treatments partially restore AMPK activation, consistent with their known metabolic signaling effects.

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TUNEL analysis of granulosa and theca cells quantifies apoptotic rates across experimental groups. PCOS induction increases apoptosis in granulosa cells, while resveratrol and metformin treatments reduce apoptotic indices toward control levels.

Figure 8

TUNEL analysis of granulosa and theca cells quantifies apoptotic rates across experimental groups. PCOS induction increases apoptosis in granulosa cells, while resveratrol and metformin treatments reduce apoptotic indices toward control levels.

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Transmission electron microscopy photomicrographs reveal ultrastructural details of oocytes, granulosa cells, and theca cells in control and PCOS groups. PCOS follicles exhibit mitochondrial swelling, dilated endoplasmic reticulum, and other signs of cellular stress.

Figure 9

Transmission electron microscopy photomicrographs reveal ultrastructural details of oocytes, granulosa cells, and theca cells in control and PCOS groups. PCOS follicles exhibit mitochondrial swelling, dilated endoplasmic reticulum, and other signs of cellular stress.

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TEM photomicrographs of resveratrol-, metformin-, and combination-treated rat ovarian tissue show improved ultrastructural features compared to untreated PCOS. Mitochondrial morphology and endoplasmic reticulum integrity are partially restored.

Figure 10

TEM photomicrographs of resveratrol-, metformin-, and combination-treated rat ovarian tissue show improved ultrastructural features compared to untreated PCOS. Mitochondrial morphology and endoplasmic reticulum integrity are partially restored.

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Figure 5

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Source Paper

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study.

Journal of ovarian research (2018)

PMID: 29958542

DOI: 10.1186/s13048-018-0427-7

Cite This Figure

![Figure 5: Histopathological analysis of ovarian sections across control and experimental groups shows characteristic PCOS features including multiple cystic follicles and thickened theca cell layers. Treatment groups demonstrate partial normalization of ovarian morphology.](https://pdfs.citedhealth.com/figures/29958542/128.png)

> Source: Selenay Furat Rencber et al. "Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCO." *Journal of ovarian research*, 2018. PMID: [29958542](https://pubmed.ncbi.nlm.nih.gov/29958542/)
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  <img src="https://pdfs.citedhealth.com/figures/29958542/128.png" alt="Histopathological analysis of ovarian sections across control and experimental groups shows characteristic PCOS features including multiple cystic follicles and thickened theca cell layers. Treatment groups demonstrate partial normalization of ovarian morphology." />
  <figcaption>Figure 5. Histopathological analysis of ovarian sections across control and experimental groups shows characteristic PCOS features including multiple cystic follicles and thickened theca cell layers. Treatment groups demonstrate partial normalization of ovarian morphology.<br>  Source: Selenay Furat Rencber et al. "Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCO." <em>Journal of ovarian research</em>, 2018. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29958542/">29958542</a></figcaption>
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