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Fig. 5 TEM photomicrographs of control and PCOS groups. Oocyte, granulosa and theca cells of follicles in control group (a-c), in PCOS group (d-i) and in solvent group (j-l). D shows the relation between oocyte-zona pellucida-granulosa cells; e-h show gra
Figure 9. Fig. 5 TEM photomicrographs of control and PCOS groups. Oocyte, granulosa and theca cells of follicles in control group (a-c), in PCOS group (d-i) and in solvent group (j-l). D shows the relation between oocyte-zona pellucida-granulosa cells; e-h show granulosa cells and I shows the theca cell layer. Note the apoptotic granulosa (e, k) and theca cells (i, l) in PCOS and solvent groups. Arrows indicate expanded perivitellin (d) and intercellular spaces (d, i); arrowheads indicate expanded sER (f) and autophagosomes (e); *: lipid droplets; dashed arrows (g, h): mitochondria with degenerated cristae. Oc: oocyte, Gc: granulosa cell, Tc: theca cell, Zp: zona pellucida. Uranyl acetate and lead citrate

描述

Transmission electron microscopy photomicrographs reveal ultrastructural details of oocytes, granulosa cells, and theca cells in control and PCOS groups. PCOS follicles exhibit mitochondrial swelling, dilated endoplasmic reticulum, and other signs of cellular stress.

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Histopathological analysis of ovarian sections across control and experimental groups shows characteristic PCOS features including multiple cystic follicles and thickened theca cell layers. Treatment groups demonstrate partial normalization of ovarian morphology.

Figure 5

Histopathological analysis of ovarian sections across control and experimental groups shows characteristic PCOS features including multiple cystic follicles and thickened theca cell layers. Treatment groups demonstrate partial normalization of ovarian morphology.

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SIRT1 immunoreactivity in ovarian tissue varies across experimental groups, with reduced expression in PCOS rats and partial restoration following resveratrol and metformin treatment. SIRT1 is implicated in cellular stress responses and metabolic regulation.

Figure 6

SIRT1 immunoreactivity in ovarian tissue varies across experimental groups, with reduced expression in PCOS rats and partial restoration following resveratrol and metformin treatment. SIRT1 is implicated in cellular stress responses and metabolic regulation.

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AMPK immunoreactivity analysis reveals decreased phosphorylated AMPK in PCOS ovarian tissue compared to controls. Both metformin and resveratrol treatments partially restore AMPK activation, consistent with their known metabolic signaling effects.

Figure 7

AMPK immunoreactivity analysis reveals decreased phosphorylated AMPK in PCOS ovarian tissue compared to controls. Both metformin and resveratrol treatments partially restore AMPK activation, consistent with their known metabolic signaling effects.

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TUNEL analysis of granulosa and theca cells quantifies apoptotic rates across experimental groups. PCOS induction increases apoptosis in granulosa cells, while resveratrol and metformin treatments reduce apoptotic indices toward control levels.

Figure 8

TUNEL analysis of granulosa and theca cells quantifies apoptotic rates across experimental groups. PCOS induction increases apoptosis in granulosa cells, while resveratrol and metformin treatments reduce apoptotic indices toward control levels.

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TEM photomicrographs of resveratrol-, metformin-, and combination-treated rat ovarian tissue show improved ultrastructural features compared to untreated PCOS. Mitochondrial morphology and endoplasmic reticulum integrity are partially restored.

Figure 10

TEM photomicrographs of resveratrol-, metformin-, and combination-treated rat ovarian tissue show improved ultrastructural features compared to untreated PCOS. Mitochondrial morphology and endoplasmic reticulum integrity are partially restored.

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Figure 9

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Source Paper

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study.

Journal of ovarian research (2018)

PMID: 29958542

DOI: 10.1186/s13048-018-0427-7

Cite This Figure

![Figure 9: Transmission electron microscopy photomicrographs reveal ultrastructural details of oocytes, granulosa cells, and theca cells in control and PCOS groups. PCOS follicles exhibit mitochondrial swelling, dilated endoplasmic reticulum, and other signs of cellular stress.](https://pdfs.citedhealth.com/figures/29958542/170.png)

> Source: Selenay Furat Rencber et al. "Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCO." *Journal of ovarian research*, 2018. PMID: [29958542](https://pubmed.ncbi.nlm.nih.gov/29958542/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/29958542/170.png" alt="Transmission electron microscopy photomicrographs reveal ultrastructural details of oocytes, granulosa cells, and theca cells in control and PCOS groups. PCOS follicles exhibit mitochondrial swelling, dilated endoplasmic reticulum, and other signs of cellular stress." />
  <figcaption>Figure 9. Transmission electron microscopy photomicrographs reveal ultrastructural details of oocytes, granulosa cells, and theca cells in control and PCOS groups. PCOS follicles exhibit mitochondrial swelling, dilated endoplasmic reticulum, and other signs of cellular stress.<br>  Source: Selenay Furat Rencber et al. "Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCO." <em>Journal of ovarian research</em>, 2018. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29958542/">29958542</a></figcaption>
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