描述
Histological analysis of wound tissue from NET-depleted and control diabetic mice reveals improved re-epithelialization and vascularization.
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Figure 3
The molecular mechanism linking NET-derived DNA to Hippo-YAP pathway inhibition and endothelial-to-mesenchymal transition is elucidated, with DNase treatment as a potential therapeutic approach.
diagram
Figure 4
In vitro endothelial-to-mesenchymal transition markers are quantified following NET exposure, demonstrating increased mesenchymal and decreased endothelial protein expression.
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Figure 5
YAP phosphorylation and nuclear exclusion in NET-treated endothelial cells are characterized, linking NET exposure to Hippo pathway activation.
chart
Figure 6
Wound healing outcomes in Padi4-knockout diabetic mice compared to wild-type controls are documented, showing accelerated closure when NET formation is genetically ablated.
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Figure 8
DNase I treatment effects on diabetic wound healing in vivo are quantified, demonstrating that NET degradation promotes wound closure through preserved endothelial function.
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Figure 9
A proposed model integrating NET-mediated Hippo pathway suppression with endothelial-to-mesenchymal transition in delayed diabetic wound healing is diagrammed.
diagramFigure 7
MicrographSource Paper
Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway.Cite This Figure
 > Source: Shuofei Yang et al. "Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothel." *International journal of biological sciences*, 2023. PMID: [36594092](https://pubmed.ncbi.nlm.nih.gov/36594092/)
<figure> <img src="https://pdfs.citedhealth.com/figures/36594092/237.png" alt="Histological analysis of wound tissue from NET-depleted and control diabetic mice reveals improved re-epithelialization and vascularization." /> <figcaption>Figure 7. Histological analysis of wound tissue from NET-depleted and control diabetic mice reveals improved re-epithelialization and vascularization.<br> Source: Shuofei Yang et al. "Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothel." <em>International journal of biological sciences</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36594092/">36594092</a></figcaption> </figure>