**Figure 4.** Figure 2. Summary of the mechanistic effects of dietary ω-3 fatty acids and polyphenols on the amyloidogenic pathway. In the context of obesity, IR, and the presence of Aβ, inflammatory pathways are upregulated. ω-3 fatty acids and polyphenols intervene in these pathways from various angles, offering potential modulation and therapeutic avenues. Akt, Ak strain transforming; APP, amyloid precursor protein; Aβ, amyloid-beta; BACE1, beta-secretase 1; CUR, curcumin; EGCG, epigallocatechin-3-gallate; GSK-3, glycogen synthase kinase 3; HFD, high-fat diet; IL18, interleukin 18; IL1β, interleukin 1 beta; IL6, interleukin 6; IRS-1, insulin receptor substrate; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein-1; NFT, neurofibrillary tangle; NF-κB, nuclear factor kappa; P, phosphorylated; QUR, quercetin; RES, resveratrol; ROS, reactive oxygen species; TNFα, tumor necrosis factor-alpha; TNFR, tumor necrosis factor receptor; ω-3, omega-3 fatty acids.

الوصف

Summary of the mechanistic effects of dietary ω-3 fatty acids and polyphenols on the amyloidogenic pathway. In the context of obesity, IR, and the presence of Aβ, inflammatory pathways are upregulated.

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Source Paper

Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids.

Nutrients (2025)

PMID: 40218960

DOI: 10.3390/nu17071203

Cite This Figure

![Figure 4: Summary of the mechanistic effects of dietary ω-3 fatty acids and polyphenols on the amyloidogenic pathway. In the context of obesity, IR, and the presence of Aβ, inflammatory pathways are upregulated.](https://pdfs.citedhealth.com/figures/40218960/247.png)

> Source: Mahsa Yavari et al. "Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects." *Nutrients*, 2025. PMID: [40218960](https://pubmed.ncbi.nlm.nih.gov/40218960/)

<figure>
  <img src="https://pdfs.citedhealth.com/figures/40218960/247.png" alt="Summary of the mechanistic effects of dietary ω-3 fatty acids and polyphenols on the amyloidogenic pathway. In the context of obesity, IR, and the presence of Aβ, inflammatory pathways are upregulated." />
  <figcaption>Figure 4. Summary of the mechanistic effects of dietary ω-3 fatty acids and polyphenols on the amyloidogenic pathway. In the context of obesity, IR, and the presence of Aβ, inflammatory pathways are upregulated.<br>  Source: Mahsa Yavari et al. "Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects." <em>Nutrients</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40218960/">40218960</a></figcaption>
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