What is the recommended dosage for Maitake Mushroom?

General: 1-3 g/day; Md Fraction: 35-70 mg/day MD-Fraction extract

What are the side effects of Maitake Mushroom?

Potential side effects include: Generally well tolerated, Mild gastrointestinal effects at high doses, Potential hypoglycemia.

What is maitake and how does it support immune health?

Maitake (Grifola frondosa) is an edible mushroom containing D-fraction beta-glucans that have been studied for their potential to activate macrophages, dendritic cells, and natural killer cells. It is one of the more researched medicinal mushrooms for immune support.

What dosage of maitake has been used in clinical trials?

Studies have used maitake D-fraction extract at doses of 35–100 mg per day, or whole maitake powder at 3–7 g per day. Clinical data in humans remains limited compared to preclinical studies.

What are the potential side effects of maitake?

Maitake is generally well tolerated as a food and supplement. Mild gastrointestinal effects may occur. It may lower blood sugar and blood pressure, so individuals on diabetes or blood pressure medications should consult a healthcare provider.

Maitake Mushroom
Maitake Mushroom

mushroom

También conocido como: Grifola frondosa, Hen of the Woods, D-Fraction, MD-Fraction

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About

Maitake (Grifola frondosa) contains MD-Fraction (beta-1,6/1,3-glucan) that activates macrophages, dendritic cells, and NK cells via Dectin-1 and complement receptor 3. It enhances Th1 cytokine response while modulating Th2 response. Licensed as a cancer adjunctive treatment in Japan.

How It Works

MD-Fraction (beta-1,6/1,3-glucan) activates macrophages, dendritic cells, and NK cells via Dectin-1 and complement receptor 3; enhances Th1 cytokine response (IL-12, IFN-gamma) while modulating Th2 response.

Evidence For Conditions

Condición	Calificación	Estudios	Participantes
Immune Aging (Immunosenescence)	C	3	100	Ver →

Side Effects

Generally well tolerated
Mild gastrointestinal effects at high doses
Potential hypoglycemia

Drug & Supplement Interactions

Diabetes medications (may lower blood sugar)
Anticoagulants (may increase bleeding risk)
Immunosuppressant medications (may counteract immunosuppression)

Informe siempre a su profesional de salud sobre todos los suplementos que toma.Siempre informe a su profesional de salud sobre todos los suplementos que toma.

Related Ingredients

Reishi Mushroom Turkey Tail Mushroom Chaga Mushroom Cordyceps

Datos rápidos

Dosificación: General: 1-3 g/day; Md_Fraction: 35-70 mg/day MD-Fraction extract
Formas: capsule powder liquid extract whole mushroom
Fuentes naturales: Wild or cultivated Grifola frondosa
Límite superior: No established UL
Mejor momento: With or without food

Resumen de evidencia

Immune Aging (Immunosenescence) C

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.