Alleviation of autoimmune disease by dietary lipids containing omega-3 fatty acids.

D R Robinson

Review Rheumatic diseases clinics of North America 1991 19 citations

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Study Design

Type d'étude: Review
Population: animal model

Intervention: Alleviation of autoimmune disease by dietary lipids containing omega-3 fatty acids. None
Comparateur: None
Critère de jugement principal: lipid levels
Direction de l'effet: Positive
Risque de biais: Unclear

Abstract

Dietary marine lipids that are enriched in omega-3, or n-3, fatty acids reduce the severity of autoimmune glomerulonephritis in several inbred murine strains. The protective effect of dietary n-3 fatty acids is also seen with a rat model of immune-complex induced vasculopathy, but no protective effects were seen with autoimmune vasculitis in the MRL/lpr mouse or with type II collagen-induced arthritis in rats. Dietary n-3 fatty acids are potential therapeutic agents for the treatment of autoimmune diseases, but careful clinical trials with the purified forms of n-3 fatty acids are needed to determine the usefulness of this intervention.

En bref

Dietary marine lipids that are enriched in omega-3, or n, fatty acids reduce the severity of autoimmune glomerulonephritis in several inbred murine strains and are potential therapeutic agents for the treatment of autoimmune diseases.

Used In Evidence Reviews

B Omega-3 Fatty Acids (EPA/DHA) pour Autoimmune Conditions

Alleviation of autoimmune disease by dietary lipids containing omega-3 fatty acids.

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Study Design

Abstract

En bref

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