What is the recommended dosage for Iron?

General: 8-18 mg/day; Deficiency: Per medical guidance based on ferritin levels

What are the side effects of Iron?

Potential side effects include: Constipation (most common), Nausea and stomach cramps, Dark or black stools, Iron overload with excessive supplementation (hemochromatosis risk).

What is iron's role in immune function?

Iron is an essential mineral required for immune cell proliferation and maturation, particularly T-cells and macrophages. Iron deficiency is associated with impaired immune responses, while iron overload can promote oxidative stress and pathogen growth.

What dosage of iron has been studied for immune-related outcomes?

Iron supplementation doses vary widely depending on deficiency status. For adults with iron deficiency, doses of 30–65 mg of elemental iron per day are common. Supplementation should be guided by serum ferritin and iron studies, not taken empirically.

What are the potential side effects of iron supplementation?

Common side effects include constipation, nausea, stomach pain, and dark stools. Excess iron can be harmful, particularly for individuals with hemochromatosis. Iron supplements should only be taken when a deficiency has been confirmed by blood testing.

Iron

mineral

Also known as: Ferrous Sulfate, Ferrous Bisglycinate, Iron Bisglycinate, Ferrous Fumarate

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About

Iron is essential for immune cell proliferation and maturation, particularly lymphocytes, and is required for the generation of reactive oxygen species by neutrophils to destroy pathogens. Iron deficiency is the most common micronutrient deficiency worldwide and significantly impairs immune cell function. Supplementation should be guided by documented deficiency, as excess iron may feed pathogens.

How It Works

Essential for immune cell proliferation and maturation; required for generation of reactive oxygen species by neutrophils to destroy pathogens; supports oxygen transport to immune tissues.

Evidence For Conditions

Condition	Grade	Studies	Participants
Pediatric Immune Support	C	5	400	View →

Side Effects

Constipation (most common)
Nausea and stomach cramps
Dark or black stools
Iron overload with excessive supplementation (hemochromatosis risk)

Drug & Supplement Interactions

Calcium supplements and dairy (reduce iron absorption by 50-60%)
Proton pump inhibitors and H2 blockers (reduce absorption)
Tetracycline and quinolone antibiotics (mutual absorption reduction)
Levothyroxine (iron reduces thyroid hormone absorption)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Selenium Zinc

Quick Facts

Dosage: General: 8-18 mg/day; Deficiency: Per medical guidance based on ferritin levels
Forms: capsule tablet liquid
Natural Sources: Red meat, Liver, Lentils, Spinach, Fortified cereals, Dark chocolate
Upper Limit: 45 mg/day (elemental iron)
Best Time: On empty stomach with vitamin C for best absorption; avoid with calcium, coffee, or tea

Evidence Summary

Pediatric Immune Support C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.