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ImmuneCited

Reishi Mushroom for Immune Aging (Immunosenescence)

C

A randomized controlled trial with 126 participants found reishi beta-glucan supplementation may significantly increase immune cell populations. Studies in cancer patients show enhanced NK cell and T-cell activity when used alongside standard treatment.

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The Bottom Line

            
            
A randomized controlled trial with 126 participants found reishi beta-glucan supplementation may significantly increase immune cell populations. Studies in cancer patients show enhanced NK cell and T-cell activity when used alongside standard treatment.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Health benefits (anti-tumor, immunomodulatory, etc.)
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: Preclinical and clinical populations

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studies

    

    

        
300

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2013
                        
                        104 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
1.5-9 g dried mushroom or 1-1.5 g extract/day

                    

                    
                    

                        
immunesupport:

                        
1,000-3,000 mg extract/day

                    

                    
                

                
                

                    Upper limit: No established UL
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: Can be taken any time; traditionally with warm water
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Gastrointestinal upset (dryness of mouth and throat, nausea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Dizziness
                        
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  • 
                            ⚠
                            Nosebleeds (antiplatelet effect)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hepatotoxicity (rare, with powdered forms)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants and antiplatelet drugs (may increase bleeding risk)
                        
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                            ●
                            Antihypertensive medications (additive blood pressure lowering)
                        
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  • 
                            ●
                            Immunosuppressant medications (may counteract immunosuppression)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may lower blood sugar)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: No established UL
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Reishi Mushroom help with Immune Aging (Immunosenescence)?
            
        
        

            Based on 5 studies with 300 participants, there is limited but promising evidence that Reishi Mushroom may support Immune Aging (Immunosenescence) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Reishi Mushroom should I take for Immune Aging (Immunosenescence)?
            
        
        

            Studies have used various dosages. A commonly studied range is 1.5-9 g dried mushroom or 1-1.5 g extract/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Reishi Mushroom?
            
        
        

            Reported side effects may include Gastrointestinal upset (dryness of mouth and throat, nausea), Dizziness, Nosebleeds (antiplatelet effect), Hepatotoxicity (rare, with powdered forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Reishi Mushroom and Immune Aging (Immunosenescence)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.