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Fig. 1 Andrographolide protected mice from radiation-induced lung injury. Mice were exposed to 18 Gy irradiation and then treated with the indicated doses of Andrographolide for 4 weeks after irradiation. a Representative images of mice at 8 weeks post-ir

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Mice exposed to 18 Gy irradiation and treated with varying doses of andrographolide for 4 weeks showed dose-dependent protection from radiation-induced lung injury. Representative images and quantitative data indicate that andrographolide significantly attenuated lung tissue damage.

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced …