What are the side effects of Conjugated Linoleic Acid?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations).

What is CLA and how does it relate to immune function?

Conjugated linoleic acid (CLA) is a group of fatty acids found naturally in meat and dairy. Some research suggests CLA may modulate inflammatory immune responses and influence cytokine production, though evidence for direct immune benefits remains preliminary.

What dosage of CLA has been studied in clinical trials?

Clinical studies have used CLA doses of 1.5–6 g per day, with 3–4 g being the most common range. Studies examining immune-related outcomes have typically lasted 8 to 12 weeks.

What are the potential side effects of CLA?

Common side effects include gastrointestinal discomfort, nausea, and loose stools. Some studies have raised concerns about CLA's effects on insulin sensitivity and liver fat accumulation at higher doses. Consult a healthcare provider before long-term use.

Conjugated Linoleic Acid

fatty_acid

Also known as: CLA

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About

Conjugated linoleic acid (CLA) modulates immune cell membrane composition and eicosanoid production. It influences PPAR-gamma activation which regulates inflammatory gene expression and may support balanced Th1/Th2 immune responses. Human evidence for immune-specific outcomes remains limited and inconsistent.

How It Works

Modulates immune cell membrane composition and eicosanoid production; influences PPAR-gamma activation regulating inflammatory gene expression; may support balanced Th1/Th2 immune responses.

Evidence For Conditions

Condition	Grade	Studies	Participants
Chronic Inflammation	D	3	150	View →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Fatigue
May worsen insulin sensitivity in some individuals
Liver fat accumulation (some formulations)

Drug & Supplement Interactions

Diabetes medications (may affect insulin sensitivity)
Anticoagulants (may have additive effects)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Omega-3 Fatty Acids (EPA/DHA)

Quick Facts

Dosage: General: 1.5-3 g/day
Forms: softgel capsule
Natural Sources: Grass-fed beef, Lamb, Full-fat dairy, Cheese
Upper Limit: No established UL
Best Time: With meals

Evidence Summary

Chronic Inflammation D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.