What are the side effects of Conjugated Linoleic Acid?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations).

What is CLA and how does it relate to immune function?

Conjugated linoleic acid (CLA) is a group of fatty acids found naturally in meat and dairy. Some research suggests CLA may modulate inflammatory immune responses and influence cytokine production, though evidence for direct immune benefits remains preliminary.

What dosage of CLA has been studied in clinical trials?

Clinical studies have used CLA doses of 1.5–6 g per day, with 3–4 g being the most common range. Studies examining immune-related outcomes have typically lasted 8 to 12 weeks.

What are the potential side effects of CLA?

Common side effects include gastrointestinal discomfort, nausea, and loose stools. Some studies have raised concerns about CLA's effects on insulin sensitivity and liver fat accumulation at higher doses. Consult a healthcare provider before long-term use.

Conjugated Linoleic Acid
Conjugated Linoleic Acid

fatty_acid

Também conhecido como: CLA

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About

O ácido linoleico conjugado (CLA) modula a composição das membranas de células imunes e a produção de eicosanoides. Influencia a ativação do PPAR-gama, que regula a expressão de genes inflamatórios e pode apoiar a função imune por meio do equilíbrio entre as respostas Th1/Th2. As evidências humanas para desfechos imunológicos específicos permanecem limitadas e inconsistentes na literatura científica atual.

How It Works

Modulates immune cell membrane composition and eicosanoid production; influences PPAR-gamma activation regulating inflammatory gene expression; may support balanced Th1/Th2 immune responses.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Chronic Inflammation	D	3	150	Ver →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Fatigue
May worsen insulin sensitivity in some individuals
Liver fat accumulation (some formulations)

Drug & Supplement Interactions

Diabetes medications (may affect insulin sensitivity)
Anticoagulants (may have additive effects)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Omega-3 Fatty Acids (EPA/DHA)

Dados Rápidos

Dosagem: General: 1.5-3 g/day
Formas: softgel capsule
Fontes Naturais: Grass-fed beef, Lamb, Full-fat dairy, Cheese
Limite Superior: No established UL
Melhor Horário: With meals

Resumo das Evidências

Chronic Inflammation D

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.