What are the side effects of Conjugated Linoleic Acid?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations).

What is CLA and how does it relate to immune function?

Conjugated linoleic acid (CLA) is a group of fatty acids found naturally in meat and dairy. Some research suggests CLA may modulate inflammatory immune responses and influence cytokine production, though evidence for direct immune benefits remains preliminary.

What dosage of CLA has been studied in clinical trials?

Clinical studies have used CLA doses of 1.5–6 g per day, with 3–4 g being the most common range. Studies examining immune-related outcomes have typically lasted 8 to 12 weeks.

What are the potential side effects of CLA?

Common side effects include gastrointestinal discomfort, nausea, and loose stools. Some studies have raised concerns about CLA's effects on insulin sensitivity and liver fat accumulation at higher doses. Consult a healthcare provider before long-term use.

Conjugated Linoleic Acid
Conjugated Linoleic Acid

fatty_acid

Juga dikenal sebagai: CLA

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About

Conjugated linoleic acid (CLA) memodelasi komposisi membran sel imun dan produksi eikosanoid. CLA memengaruhi aktivasi PPAR-gamma yang mengatur ekspresi gen inflamasi dan dapat mendukung keseimbangan respons imun Th1/Th2. Namun, bukti klinis pada manusia untuk hasil spesifik yang berkaitan dengan fungsi imun masih terbatas dan tidak konsisten.

How It Works

Modulates immune cell membrane composition and eicosanoid production; influences PPAR-gamma activation regulating inflammatory gene expression; may support balanced Th1/Th2 immune responses.

Evidence For Conditions

Kondisi	Peringkat	Studi	Peserta
Chronic Inflammation	D	3	150	Lihat →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Fatigue
May worsen insulin sensitivity in some individuals
Liver fat accumulation (some formulations)

Drug & Supplement Interactions

Diabetes medications (may affect insulin sensitivity)
Anticoagulants (may have additive effects)

Selalu informasikan kepada tenaga kesehatan Anda tentang semua suplemen yang Anda konsumsi.Selalu informasikan penyedia layanan kesehatan Anda tentang semua suplemen yang Anda konsumsi.

Related Ingredients

Omega-3 Fatty Acids (EPA/DHA)

Fakta Singkat

Dosis: General: 1.5-3 g/day
Bentuk Sediaan: softgel capsule
Sumber Alami: Grass-fed beef, Lamb, Full-fat dairy, Cheese
Batas Atas: No established UL
Waktu Terbaik: With meals

Ringkasan Bukti

Chronic Inflammation D

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