What is the recommended dosage for Omega-3 Fatty Acids (EPA/DHA)?

General: 250-500 mg combined EPA/DHA/day; Anti Inflammatory: 1,000-3,000 mg combined EPA/DHA/day

What are the side effects of Omega-3 Fatty Acids (EPA/DHA)?

Potential side effects include: Fishy aftertaste and burping, Gastrointestinal discomfort (nausea, diarrhea), Increased bleeding risk at high doses, Potential LDL cholesterol increase at very high doses.

What is omega-3 and how does it support immune function?

Omega-3 fatty acids (EPA and DHA) are essential polyunsaturated fats found in fish oil and algae. They play a role in resolving inflammation through specialized pro-resolving mediators (SPMs) and have been studied for their effects on immune cell membrane function.

What dosage of omega-3 has been studied for immune-related outcomes?

Clinical trials have used omega-3 doses of 1–4 g per day of combined EPA and DHA. For immune and anti-inflammatory outcomes, doses of 2–3 g per day are common, typically studied over periods of 8 to 16 weeks.

What are the potential side effects of omega-3 supplementation?

Common side effects include fishy aftertaste, burping, and mild gastrointestinal effects. High doses (above 3 g per day) may increase bleeding risk and should be discussed with a healthcare provider, especially before surgery or if taking anticoagulants.

Omega-3 Fatty Acids (EPA/DHA)
Omega-3 Fatty Acids (EPA/DHA)

fatty_acid

Juga dikenal sebagai: Fish Oil, Eicosapentaenoic Acid, Docosahexaenoic Acid, Marine Omega-3

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About

EPA dan DHA mengubah komposisi fosfolipid membran sel dan menghasilkan mediator pro-resolving khusus (resolvin, protektin, maressin) yang secara aktif memodelasi respons inflamasi. Uji klinis VITAL menunjukkan penurunan risiko penyakit autoimun sebesar 15%. DHA menunjukkan efek anti-inflamasi yang lebih kuat dibandingkan EPA dalam studi acak terkontrol.

How It Works

EPA and DHA alter cell membrane phospholipid composition and give rise to specialized pro-resolving mediators (resolvins, protectins, maresins); EPA inhibits NF-kB activation; DHA suppresses pro-inflammatory gene expression.

Evidence For Conditions

Kondisi	Peringkat	Studi	Peserta
Chronic Inflammation	A	30	30000	Lihat →
Autoimmune Conditions	B	10	25000	Lihat →

Side Effects

Fishy aftertaste and burping
Gastrointestinal discomfort (nausea, diarrhea)
Increased bleeding risk at high doses
Potential LDL cholesterol increase at very high doses

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
Blood pressure medications (additive blood pressure lowering)
Orlistat (may reduce omega-3 absorption)
Cyclosporine (may modify immunosuppressive effects)

Selalu informasikan kepada tenaga kesehatan Anda tentang semua suplemen yang Anda konsumsi.Selalu informasikan penyedia layanan kesehatan Anda tentang semua suplemen yang Anda konsumsi.

Related Ingredients

Conjugated Linoleic Acid

Fakta Singkat

Dosis: General: 250-500 mg combined EPA/DHA/day; Anti_Inflammatory: 1,000-3,000 mg combined EPA/DHA/day
Bentuk Sediaan: softgel liquid capsule
Sumber Alami: Salmon, Mackerel, Sardines, Anchovies, Walnuts, Flaxseed
Batas Atas: 3,000 mg/day EPA+DHA (FDA-recognized as safe)
Waktu Terbaik: With meals

Ringkasan Bukti

Chronic Inflammation A

Autoimmune Conditions B

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