Endocrine risk factors for COVID-19 in context of aging.

L Máčová, M Bičíková, R Hampl

Review Physiological research 2021 2 citazioni

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Study Design

Tipo di studio: Review
Popolazione: impairment of disorder

Intervento: Endocrine risk factors for COVID-19 in context of aging. None
Comparatore: None
Esito primario: None
Direzione dell'effetto: Positive
Rischio di bias: Unclear

Abstract

Aged people are the most susceptible group to COVID-19 infection. Immunosenescence characterized by impairment of immune function with inflamm-aging contributes to pathophysiological alterations, among which endocrine and metabolic diseases are not exception. Diabetes, obesity along with impairment of disorders of thyroid functions are the most frequent ones, the common feature of which is failure of immune system including autoimmune processes. In the minireview we discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes. Mentioned is also beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues. Particular attention is devoted to the role of ACE2 protein in the light of its intimate link with renin-angiotensin regulating system.

TL;DR

In the minireview, it is discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes, and beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues.

Used In Evidence Reviews

B Vitamin D per Immune Aging (Immunosenescence)

Endocrine risk factors for COVID-19 in context of aging.

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Study Design

Abstract

TL;DR

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