Endocrine risk factors for COVID-19 in context of aging.

L Máčová, M Bičíková, R Hampl

Review Physiological research 2021 2 次引用

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Study Design

研究类型: Review
研究人群: impairment of disorder

干预措施: Endocrine risk factors for COVID-19 in context of aging. None
对照组: None
主要结局: None
效应方向: Positive
偏倚风险: Unclear

Abstract

Aged people are the most susceptible group to COVID-19 infection. Immunosenescence characterized by impairment of immune function with inflamm-aging contributes to pathophysiological alterations, among which endocrine and metabolic diseases are not exception. Diabetes, obesity along with impairment of disorders of thyroid functions are the most frequent ones, the common feature of which is failure of immune system including autoimmune processes. In the minireview we discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes. Mentioned is also beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues. Particular attention is devoted to the role of ACE2 protein in the light of its intimate link with renin-angiotensin regulating system.

简要概述

In the minireview, it is discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes, and beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues.

Used In Evidence Reviews

B Vitamin D 用于 Immune Aging (Immunosenescence)

Endocrine risk factors for COVID-19 in context of aging.

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Study Design

Abstract

简要概述

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