What are the side effects of Conjugated Linoleic Acid?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations).

What is CLA and how does it relate to immune function?

Conjugated linoleic acid (CLA) is a group of fatty acids found naturally in meat and dairy. Some research suggests CLA may modulate inflammatory immune responses and influence cytokine production, though evidence for direct immune benefits remains preliminary.

What dosage of CLA has been studied in clinical trials?

Clinical studies have used CLA doses of 1.5–6 g per day, with 3–4 g being the most common range. Studies examining immune-related outcomes have typically lasted 8 to 12 weeks.

What are the potential side effects of CLA?

Common side effects include gastrointestinal discomfort, nausea, and loose stools. Some studies have raised concerns about CLA's effects on insulin sensitivity and liver fat accumulation at higher doses. Consult a healthcare provider before long-term use.

Conjugated Linoleic Acid
Conjugated Linoleic Acid

fatty_acid

Также известен как: CLA

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About

Conjugated linoleic acid (CLA) modulates immune cell membrane composition and eicosanoid production. It influences PPAR-gamma activation which regulates inflammatory gene expression and may support balanced Th1/Th2 immune responses. Human evidence for immune-specific outcomes remains limited and inconsistent.

How It Works

Modulates immune cell membrane composition and eicosanoid production; influences PPAR-gamma activation regulating inflammatory gene expression; may support balanced Th1/Th2 immune responses.

Evidence For Conditions

Состояние	Оценка	Исследования	Участники
Chronic Inflammation	D	3	150	Подробнее →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Fatigue
May worsen insulin sensitivity in some individuals
Liver fat accumulation (some formulations)

Drug & Supplement Interactions

Diabetes medications (may affect insulin sensitivity)
Anticoagulants (may have additive effects)

Всегда сообщайте лечащему врачу обо всех принимаемых добавках.

Related Ingredients

Omega-3 Fatty Acids (EPA/DHA)

Основные факты

Дозировка: General: 1.5-3 g/day
Формы выпуска: softgel capsule
Природные источники: Grass-fed beef, Lamb, Full-fat dairy, Cheese
Верхний предел: No established UL
Лучшее время приёма: With meals

Обзор доказательной базы

Chronic Inflammation D

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.