Vitamin E cho Immune Aging (Immunosenescence)

Clinical trials in elderly populations demonstrate vitamin E supplementation at 200 IU/day may enhance delayed-type hypersensitivity (DTH) skin test response and antibody production. Recognized as one of the most effective single nutrients for modulating immune function in older adults.

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Key Study Findings

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None so với: None Outcome: Micronutrient deficiency management in pediatric IBD Hiệu quả: None None

Đối tượng nghiên cứu: Children with inflammatory bowel disease (review)

Observational Study n=2065

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE …

Dose: None so với: None Outcome: CMV IgG association with oxidative stress markers Hiệu quả: None None

Đối tượng nghiên cứu: Age-stratified general population (MARK-AGE RASIG cohort)

In Vitro

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction.

Dose: None so với: Untreated HFDPCs; finasteride, dutasteride, minoxidil Outcome: SRD5A1-3 and TGF-beta1 expression Hiệu quả: HFDPC proliferation 139.4+/-1.1% at 72h p<0.05

Đối tượng nghiên cứu: Human hair follicle dermal papilla cells (in vitro)

Review

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on …

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Elderly with immunosenescence

Other

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels …

Dose: 100 mg so với: control Outcome: None Hiệu quả: or 1 None

Đối tượng nghiên cứu: None

Review n=26282 988 weeks

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES.

Dose: 45% so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: None

Key Statistics

Nghiên cứu

600

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 trích dẫn

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. Other

Biogerontology 2025

Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction. Other

Foods (Basel, Switzerland) 2025

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota. Review

Advances in nutrition … 2022 1 trích dẫn

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 trích dẫn

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Review

Nutrients 2020 75 trích dẫn

Vitamin C and vitamin C plus E improve the immune function in the elderly. Other

Experimental gerontology 2020 49 trích dẫn

Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management. Review

Medecine et maladies … 2019 44 trích dẫn

Voluntary exercise reverses immune aging induced by oxidative stress in aging mice. Other

Experimental gerontology 2019 24 trích dẫn

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 trích dẫn

Nutritional modulation of age-related changes in the immune system and risk of infection. Review

Nutrition research (New … 2017 67 trích dẫn

Comparison of AS03 and Alum on immune responses elicited by A/H3N2 split influenza vaccine in young, mature and aged BALB/c … Other

Vaccine 2016 27 trích dẫn

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 trích dẫn

Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Review

Endocrine, metabolic & … 2014 84 trích dẫn

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 trích dẫn

Chemoprevention of prostate cancer. Review

Annual review of … 2014 9 trích dẫn

The role of nutrition in enhancing immunity in aging. Other

Aging and disease 2012 209 trích dẫn

Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C … RCT

The British journal … 2012 40 trích dẫn

The effect of age on the immune response of horses to vaccination. Other

Journal of comparative … 2010 17 trích dẫn

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. Review

Journal of leukocyte … 2008 177 trích dẫn

The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E. Other

The Journal of … 2008 34 trích dẫn

Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. Other

Antioxidants & redox … 2003 26 trích dẫn

The immune system: a target for functional foods? Review

The British journal … 2002 358 trích dẫn

Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Other

Vaccine 2000 35 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 15 mg/day (22.4 IU)
immunesupportelderly:: 200 IU/day

Giới hạn trên: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Neutral	--
None	--	Negative	2065
None	--	Positive	--
None	--	Mixed	--
100 mg	--	Positive	--
45%	988 weeks	Positive	26282
500 mg	12 weeks	Mixed	--
None	--	Mixed	--

Thời điểm dùng tốt nhất: With meals containing fat

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Increased bleeding risk at high doses (>400 IU/day)
⚠ Nausea and gastrointestinal distress
⚠ Fatigue and muscle weakness at very high doses
⚠ Potential increased mortality risk at chronic high doses (meta-analysis finding, debated)

Tương tác đã biết

● Anticoagulants and antiplatelet drugs (increased bleeding risk)
● Statins (may reduce statin effectiveness)
● Chemotherapy agents (may interfere with oxidative mechanisms)
● Vitamin K (high-dose vitamin E may antagonize vitamin K)

Mức hấp thụ tối đa cho phép: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Vitamin E help with Immune Aging (Immunosenescence)?

Based on 5 studies with 600 participants, there is moderate evidence from clinical studies that Vitamin E may support Immune Aging (Immunosenescence) management. Our evidence grade is B (Good Evidence).

How much Vitamin E should I take for Immune Aging (Immunosenescence)?

Studies have used various dosages. A commonly studied range is 15 mg/day (22.4 IU). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses (>400 IU/day), Nausea and gastrointestinal distress, Fatigue and muscle weakness at very high doses, Potential increased mortality risk at chronic high doses (meta-analysis finding, debated). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Immune Aging (Immunosenescence)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

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Đánh giá nhanh

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (3)Meta (0)Other (2)

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