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Mitochondrial biogenesis pathways regulated by PGC-1alpha and related transcription factors are illustrated, showing how specific supplements may enhance new mitochondria production in RPE cells.

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![Figure 4: Mitochondrial biogenesis pathways regulated by PGC-1alpha and related transcription factors are illustrated, showing how specific supplements may enhance new mitochondria production in RPE cells.]()

> Source: Lidianys María Lewis Luján et al. "Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat." *Nutrients*, 2022. PMID: [35565950](https://pubmed.ncbi.nlm.nih.gov/35565950/)
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  <img src="" alt="Mitochondrial biogenesis pathways regulated by PGC-1alpha and related transcription factors are illustrated, showing how specific supplements may enhance new mitochondria production in RPE cells." />
  <figcaption>Figure 4. Mitochondrial biogenesis pathways regulated by PGC-1alpha and related transcription factors are illustrated, showing how specific supplements may enhance new mitochondria production in RPE cells.<br>  Source: Lidianys María Lewis Luján et al. "Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat." <em>Nutrients</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35565950/">35565950</a></figcaption>
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