Vitamin D für Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
Fazit
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs.: None
Outcome: rheumatoid arthritis disease activity modulation through diet
Wirkung: None
None
Population: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs.: None
Outcome: RA risk and disease activity
Wirkung: None
None
Population: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs.: None
Outcome: None
Wirkung: None
None
Population: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs.: None
Outcome: None
Wirkung: None
None
Population: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs.: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
Wirkung: None
None
Population: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs.: None
Outcome: Neuroprotection
Wirkung: None
None
Population: None
Key Statistics
3
Studien
25871
Teilnehmer
↑
Positive
A
Bewertung
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 Zitierungen
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 Zitierungen
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 Zitierungen
Immunity & ageing …
2024
12 Zitierungen
Frontiers in immunology
2024
9 Zitierungen
Autoimmunity reviews
2024
6 Zitierungen
Biochemical pharmacology
2024
6 Zitierungen
Indian dermatology online …
2024
3 Zitierungen
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 Zitierungen
Biomolecules
2023
70 Zitierungen
Autoimmunity reviews
2023
65 Zitierungen
The American journal …
2023
37 Zitierungen
Frontiers in immunology
2023
33 Zitierungen
Nutrients
2023
24 Zitierungen
Seminars in arthritis …
2023
17 Zitierungen
Mini reviews in …
2023
9 Zitierungen
Journal of cosmetic …
2023
4 Zitierungen
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 Zitierungen
International journal of …
2022
102 Zitierungen
Endocrine connections
2022
50 Zitierungen
Nutrients
2022
29 Zitierungen
Pathophysiology : the …
2022
24 Zitierungen
Frontiers in bioscience …
2022
17 Zitierungen
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 Zitierungen
BMJ (Clinical research …
2022
9 Zitierungen
Nederlands tijdschrift voor …
2022
1 Zitierungen
Medical sciences (Basel, …
2021
157 Zitierungen
International journal of …
2021
6 Zitierungen
JAAD international
2021
5 Zitierungen
Nutrients
2020
229 Zitierungen
Calcified tissue international
2020
185 Zitierungen
Nutrients
2020
41 Zitierungen
Acta biochimica Polonica
2020
10 Zitierungen
Advances in experimental …
2020
8 Zitierungen
Journal of autoimmunity
2019
604 Zitierungen
International journal of …
2019
109 Zitierungen
The genetics of vitamin D.
Review
Bone
2019
62 Zitierungen
Therapeutics and clinical …
2019
4 Zitierungen
Journal of research …
2018
48 Zitierungen
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 Zitierungen
Thyroid : official …
2017
170 Zitierungen
The Israel Medical …
2017
117 Zitierungen
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 Zitierungen
Clinical reviews in …
2017
46 Zitierungen
Postepy dermatologii i …
2017
31 Zitierungen
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 Zitierungen
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 Zitierungen
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 Zitierungen
Postepy dermatologii i …
2016
59 Zitierungen
Indian dermatology online …
2016
51 Zitierungen
Current gastroenterology reports
2016
22 Zitierungen
Nutrients
2015
210 Zitierungen
Frontiers in immunology
2015
102 Zitierungen
Journal of drugs …
2015
50 Zitierungen
The Proceedings of …
2015
46 Zitierungen
Clinica chimica acta; …
2015
43 Zitierungen
Healthcare (Basel, Switzerland)
2015
7 Zitierungen
Vitamin D and immunity.
Review
F1000prime reports
2014
79 Zitierungen
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 Zitierungen
Clinical reviews in …
2013
259 Zitierungen
British journal of …
2013
156 Zitierungen
Dermato-endocrinology
2013
62 Zitierungen
Clinics and research …
2013
56 Zitierungen
Multiple sclerosis.
Review
Global advances in …
2013
19 Zitierungen
Presse medicale (Paris, …
2013
4 Zitierungen
Journal of investigative …
2011
563 Zitierungen
Vitamins and hormones
2011
25 Zitierungen
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 Zitierungen
Acta medica Indonesiana
2007
4 Zitierungen
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 Zitierungen
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 Zitierungen
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Obergrenze: 4,000 IU/day (100 mcg)
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
Beste Einnahmezeit: With a meal containing fat for better absorption
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Bekannte Wechselwirkungen
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Tolerierbare Höchstaufnahmemenge: 4,000 IU/day (100 mcg)
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
Andere Inhaltsstoffe für Autoimmune Conditions
Vitamin D für andere Beschwerden
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