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비타민 D 관련 자가면역 질환

A 근거 여러 대규모 임상 시험이 일관되게 유의미한 효과를 보여줍니다.

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

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A

결론

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

Key Study Findings

Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None vs: None Outcome: rheumatoid arthritis disease activity modulation through diet 효과: None None

대상 집단: patients with rheumatoid arthritis

Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None vs: None Outcome: RA risk and disease activity 효과: None None

대상 집단: Patients with rheumatoid arthritis

Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None vs: None Outcome: None 효과: None None

대상 집단: None

Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None vs: None Outcome: None 효과: None None

대상 집단: Systematic review of nutraceuticals in rheumatoid arthritis

Controlled Clinical Trial 26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily vs: No supplementation Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI) 효과: None None

대상 집단: SLE patients (EULAR/ACR 2019 criteria)

Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None vs: None Outcome: Neuroprotection 효과: None None

대상 집단: None

Key Statistics

3

연구

25871

참여자

Positive

A

등급

Referenced Papers

Nature reviews. Endocrinology 2025 14 인용
Autoimmunity reviews 2024 6 인용
Biomolecules 2023 70 인용
Endocrine connections 2022 50 인용
Pathophysiology : the … 2022 24 인용
Frontiers in bioscience … 2022 17 인용
BMJ (Clinical research … 2022 9 인용
Medical sciences (Basel, … 2021 157 인용
Calcified tissue international 2020 185 인용
Acta biochimica Polonica 2020 10 인용
Advances in experimental … 2020 8 인용
Journal of autoimmunity 2019 604 인용
International journal of … 2019 109 인용
Bone 2019 62 인용
Journal of research … 2018 48 인용
Wiadomosci lekarskie (Warsaw, … 2018 2 인용
Analytical biochemistry 2017 47 인용
Clinical reviews in … 2017 46 인용
Postepy dermatologii i … 2017 31 인용
Scandinavian journal of … 2016 81 인용
Postepy dermatologii i … 2016 59 인용
Indian dermatology online … 2016 51 인용
Current gastroenterology reports 2016 22 인용
Frontiers in immunology 2015 102 인용
Clinica chimica acta; … 2015 43 인용
Healthcare (Basel, Switzerland) 2015 7 인용
F1000prime reports 2014 79 인용
Pediatric clinics of … 2014 25 인용
Clinical reviews in … 2013 259 인용
British journal of … 2013 156 인용
Clinics and research … 2013 56 인용
Global advances in … 2013 19 인용
Presse medicale (Paris, … 2013 4 인용
Journal of investigative … 2011 563 인용
Vitamins and hormones 2011 25 인용
Molecular oncology 2011
Acta medica Indonesiana 2007 4 인용
American family physician 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:
600-800 IU/day
immunesupport:
1,000-2,000 IU/day
deficiencycorrection:
4,000-5,000 IU/day (under medical supervision)

상한량: 4,000 IU/day (100 mcg)

연구에서 사용된 용량

용량 기간 효과 N
None -- Positive --
None -- Positive --
None -- Mixed --
None -- Mixed --
4000 IU or 8000 IU daily 26 weeks Positive --
None -- Positive --
None -- Neutral --
None -- Neutral --

권장 복용 시간: With a meal containing fat for better absorption

Safety & Side Effects

보고된 부작용

  • Hypercalcemia at very high doses (nausea, vomiting, weakness)
  • Kidney stones with excessive long-term use
  • Constipation
  • Metallic taste

알려진 상호작용

  • Thiazide diuretics (may increase risk of hypercalcemia)
  • Corticosteroids (reduce vitamin D absorption and metabolism)
  • Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
  • Statins (vitamin D may affect statin metabolism)

일일 최대 섭취 허용량: 4,000 IU/day (100 mcg)

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 비타민 D help with 자가면역 질환?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that 비타민 D may support 자가면역 질환 management. Our evidence grade is A (Strong Evidence).
How much 비타민 D should I take for 자가면역 질환?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 비타민 D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 비타민 D and 자가면역 질환?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.

관련 다른 성분: 자가면역 질환

비타민 D 다른 건강 상태에 대한 근거

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FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.