Vitamin D 관련 Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
결론
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs: None
Outcome: rheumatoid arthritis disease activity modulation through diet
효과: None
None
대상 집단: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs: None
Outcome: RA risk and disease activity
효과: None
None
대상 집단: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
효과: None
None
대상 집단: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs: None
Outcome: Neuroprotection
효과: None
None
대상 집단: None
Key Statistics
3
연구
25871
참여자
↑
Positive
A
등급
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 인용
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 인용
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 인용
Immunity & ageing …
2024
12 인용
Frontiers in immunology
2024
9 인용
Autoimmunity reviews
2024
6 인용
Biochemical pharmacology
2024
6 인용
Indian dermatology online …
2024
3 인용
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 인용
Biomolecules
2023
70 인용
Autoimmunity reviews
2023
65 인용
The American journal …
2023
37 인용
Frontiers in immunology
2023
33 인용
Nutrients
2023
24 인용
Seminars in arthritis …
2023
17 인용
Mini reviews in …
2023
9 인용
Journal of cosmetic …
2023
4 인용
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 인용
International journal of …
2022
102 인용
Endocrine connections
2022
50 인용
Nutrients
2022
29 인용
Pathophysiology : the …
2022
24 인용
Frontiers in bioscience …
2022
17 인용
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 인용
BMJ (Clinical research …
2022
9 인용
Nederlands tijdschrift voor …
2022
1 인용
Medical sciences (Basel, …
2021
157 인용
International journal of …
2021
6 인용
JAAD international
2021
5 인용
Nutrients
2020
229 인용
Calcified tissue international
2020
185 인용
Nutrients
2020
41 인용
Acta biochimica Polonica
2020
10 인용
Advances in experimental …
2020
8 인용
Journal of autoimmunity
2019
604 인용
International journal of …
2019
109 인용
The genetics of vitamin D.
Review
Bone
2019
62 인용
Therapeutics and clinical …
2019
4 인용
Journal of research …
2018
48 인용
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 인용
Thyroid : official …
2017
170 인용
The Israel Medical …
2017
117 인용
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 인용
Clinical reviews in …
2017
46 인용
Postepy dermatologii i …
2017
31 인용
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 인용
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 인용
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 인용
Postepy dermatologii i …
2016
59 인용
Indian dermatology online …
2016
51 인용
Current gastroenterology reports
2016
22 인용
Nutrients
2015
210 인용
Frontiers in immunology
2015
102 인용
Journal of drugs …
2015
50 인용
The Proceedings of …
2015
46 인용
Clinica chimica acta; …
2015
43 인용
Healthcare (Basel, Switzerland)
2015
7 인용
Vitamin D and immunity.
Review
F1000prime reports
2014
79 인용
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 인용
Clinical reviews in …
2013
259 인용
British journal of …
2013
156 인용
Dermato-endocrinology
2013
62 인용
Clinics and research …
2013
56 인용
Multiple sclerosis.
Review
Global advances in …
2013
19 인용
Presse medicale (Paris, …
2013
4 인용
Journal of investigative …
2011
563 인용
Vitamins and hormones
2011
25 인용
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 인용
Acta medica Indonesiana
2007
4 인용
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 인용
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
상한량: 4,000 IU/day (100 mcg)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
권장 복용 시간: With a meal containing fat for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
알려진 상호작용
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
일일 최대 섭취 허용량: 4,000 IU/day (100 mcg)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: Autoimmune Conditions
Vitamin D 다른 건강 상태에 대한 근거
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