Vitamin D 用于 Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
结论
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs: None
Outcome: rheumatoid arthritis disease activity modulation through diet
效果: None
None
研究人群: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs: None
Outcome: RA risk and disease activity
效果: None
None
研究人群: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
效果: None
None
研究人群: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs: None
Outcome: Neuroprotection
效果: None
None
研究人群: None
Key Statistics
3
研究数量
25871
受试者
↑
Positive
A
等级
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 次引用
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 次引用
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 次引用
Immunity & ageing …
2024
12 次引用
Frontiers in immunology
2024
9 次引用
Autoimmunity reviews
2024
6 次引用
Biochemical pharmacology
2024
6 次引用
Indian dermatology online …
2024
3 次引用
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 次引用
Biomolecules
2023
70 次引用
Autoimmunity reviews
2023
65 次引用
The American journal …
2023
37 次引用
Frontiers in immunology
2023
33 次引用
Nutrients
2023
24 次引用
Seminars in arthritis …
2023
17 次引用
Mini reviews in …
2023
9 次引用
Journal of cosmetic …
2023
4 次引用
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 次引用
International journal of …
2022
102 次引用
Endocrine connections
2022
50 次引用
Nutrients
2022
29 次引用
Pathophysiology : the …
2022
24 次引用
Frontiers in bioscience …
2022
17 次引用
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 次引用
BMJ (Clinical research …
2022
9 次引用
Nederlands tijdschrift voor …
2022
1 次引用
Medical sciences (Basel, …
2021
157 次引用
International journal of …
2021
6 次引用
JAAD international
2021
5 次引用
Nutrients
2020
229 次引用
Calcified tissue international
2020
185 次引用
Nutrients
2020
41 次引用
Acta biochimica Polonica
2020
10 次引用
Advances in experimental …
2020
8 次引用
Journal of autoimmunity
2019
604 次引用
International journal of …
2019
109 次引用
The genetics of vitamin D.
Review
Bone
2019
62 次引用
Therapeutics and clinical …
2019
4 次引用
Journal of research …
2018
48 次引用
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 次引用
Thyroid : official …
2017
170 次引用
The Israel Medical …
2017
117 次引用
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 次引用
Clinical reviews in …
2017
46 次引用
Postepy dermatologii i …
2017
31 次引用
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 次引用
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 次引用
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 次引用
Postepy dermatologii i …
2016
59 次引用
Indian dermatology online …
2016
51 次引用
Current gastroenterology reports
2016
22 次引用
Nutrients
2015
210 次引用
Frontiers in immunology
2015
102 次引用
Journal of drugs …
2015
50 次引用
The Proceedings of …
2015
46 次引用
Clinica chimica acta; …
2015
43 次引用
Healthcare (Basel, Switzerland)
2015
7 次引用
Vitamin D and immunity.
Review
F1000prime reports
2014
79 次引用
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 次引用
Clinical reviews in …
2013
259 次引用
British journal of …
2013
156 次引用
Dermato-endocrinology
2013
62 次引用
Clinics and research …
2013
56 次引用
Multiple sclerosis.
Review
Global advances in …
2013
19 次引用
Presse medicale (Paris, …
2013
4 次引用
Journal of investigative …
2011
563 次引用
Vitamins and hormones
2011
25 次引用
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 次引用
Acta medica Indonesiana
2007
4 次引用
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 次引用
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
上限： 4,000 IU/day (100 mcg)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
最佳服用时间： With a meal containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
已知相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
可耐受最高摄入量： 4,000 IU/day (100 mcg)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Autoimmune Conditions
Vitamin D 用于其他健康状况
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