Vitamin D 用于 上呼吸道感染
A 证据 多项大型临床试验一致显示出显著的益处。Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
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A
结论
Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Elite/professional cyclists nutrition review
Systematic Review
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Dose: Disease-modifying agents (tolvaptan, etc.)
vs: Placebo or standard care
Outcome: Kidney disease progression
效果: None
None
研究人群: Patients with ADPKD
Review
Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …
Dose: Probiotics, nutraceuticals
vs: None
Outcome: Immune response modulation in COVID-19
效果: None
None
研究人群: COVID-19 patients with gut dysbiosis
Review
Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature.
Dose: 600-800 IU (DRI) or higher
vs: None
Outcome: Skeletal and extra-skeletal health benefits
效果: None
None
研究人群: General population (guideline comparison)
Meta-Analysis
n=5748
High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 …
Dose: 400 IU
vs: Placebo
Outcome: None
效果: None
None
研究人群: Healthy adults
Case-Control
26.0 weeks
Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection.
Dose: 98%
vs: control
Outcome: None
效果: None
None
研究人群: None
Key Statistics
40
研究数量
30000
受试者
↑
Positive
A
等级
Referenced Papers
International journal of …
2025
2 次引用
Endocrine practice : …
2024
24 次引用
Nutrition reviews
2024
9 次引用
Journal of translational …
2024
2 次引用
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 次引用
Indian journal of …
2023
Dermatologic therapy
2022
42 次引用
Clinical nutrition (Edinburgh, …
2022
17 次引用
Medicine and science …
2021
18 次引用
Vitamin D and upper respiratory tract infections in young active males exposed to cold environments.
Other
Annals of agricultural …
2021
3 次引用
The World Allergy …
2020
16 次引用
Nutrients
2020
1 次引用
The Pediatric infectious …
2019
15 次引用
European archives of …
2019
14 次引用
Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes.
Observational
The Journal of …
2019
9 次引用
Indian journal of …
2019
3 次引用
International journal of …
2018
165 次引用
International journal of …
2018
37 次引用
The journal of …
2018
27 次引用
JAMA
2017
131 次引用
Public health nutrition
2017
6 次引用
European journal of …
2016
93 次引用
American journal of …
2016
45 次引用
Journal of general …
2016
38 次引用
International journal of …
2016
22 次引用
Epidemiology and infection
2016
13 次引用
[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease].
Other
Zhongguo dang dai …
2016
5 次引用
European journal of …
2016
BMC infectious diseases
2014
58 次引用
Clinical infectious diseases …
2013
129 次引用
Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial.
RCT
Clinical infectious diseases …
2013
58 次引用
Indian journal of …
2013
24 次引用
Acta scientiarum polonorum. …
2012
11 次引用
International journal of …
2011
49 次引用
The Journal of …
2010
93 次引用
Journal of the …
2010
11 次引用
Archives of internal …
2009
975 次引用
Clinical journal of …
2008
148 次引用
International journal of …
2002
26 次引用
Manometric study in Kearns-Sayre syndrome.
Case Report
Diseases of the …
2001
7 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
上限： 4,000 IU/day (100 mcg)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Disease-modifying agents (tolvaptan, etc.) | -- | Positive | -- |
| Probiotics, nutraceuticals | -- | Positive | -- |
| 600-800 IU (DRI) or higher | -- | Positive | -- |
| 400 IU | -- | Negative | 5748 |
| 98% | 26.0 weeks | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 50554 |
最佳服用时间： With a meal containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
已知相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
可耐受最高摄入量： 4,000 IU/day (100 mcg)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with 上呼吸道感染?
Based on 40 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Vitamin D may support 上呼吸道感染 management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for 上呼吸道感染?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and 上呼吸道感染?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 40 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 上呼吸道感染
References
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