Vitamin D لـ Upper Respiratory Tract Infections
A الأدلة تُظهر تجارب سريرية كبيرة متعددة باستمرار فوائد ملحوظة.Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
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A
الخلاصة
Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: Elite/professional cyclists nutrition review
Systematic Review
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Dose: Disease-modifying agents (tolvaptan, etc.)
مقابل: Placebo or standard care
Outcome: Kidney disease progression
التأثير: None
None
المجتمع المدروس: Patients with ADPKD
Review
Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …
Dose: Probiotics, nutraceuticals
مقابل: None
Outcome: Immune response modulation in COVID-19
التأثير: None
None
المجتمع المدروس: COVID-19 patients with gut dysbiosis
Review
Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature.
Dose: 600-800 IU (DRI) or higher
مقابل: None
Outcome: Skeletal and extra-skeletal health benefits
التأثير: None
None
المجتمع المدروس: General population (guideline comparison)
Meta-Analysis
n=5748
High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 …
Dose: 400 IU
مقابل: Placebo
Outcome: None
التأثير: None
None
المجتمع المدروس: Healthy adults
Case-Control
26.0 weeks
Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection.
Dose: 98%
مقابل: control
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Key Statistics
40
الدراسات
30000
المشاركون
↑
Positive
A
التقييم
Referenced Papers
International journal of …
2025
2 اقتباسات
Endocrine practice : …
2024
24 اقتباسات
Nutrition reviews
2024
9 اقتباسات
Journal of translational …
2024
2 اقتباسات
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 اقتباسات
Indian journal of …
2023
Dermatologic therapy
2022
42 اقتباسات
Clinical nutrition (Edinburgh, …
2022
17 اقتباسات
Medicine and science …
2021
18 اقتباسات
Vitamin D and upper respiratory tract infections in young active males exposed to cold environments.
Other
Annals of agricultural …
2021
3 اقتباسات
The World Allergy …
2020
16 اقتباسات
Nutrients
2020
1 اقتباسات
The Pediatric infectious …
2019
15 اقتباسات
European archives of …
2019
14 اقتباسات
Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes.
Observational
The Journal of …
2019
9 اقتباسات
Indian journal of …
2019
3 اقتباسات
International journal of …
2018
165 اقتباسات
International journal of …
2018
37 اقتباسات
The journal of …
2018
27 اقتباسات
JAMA
2017
131 اقتباسات
Public health nutrition
2017
6 اقتباسات
European journal of …
2016
93 اقتباسات
American journal of …
2016
45 اقتباسات
Journal of general …
2016
38 اقتباسات
International journal of …
2016
22 اقتباسات
Epidemiology and infection
2016
13 اقتباسات
[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease].
Other
Zhongguo dang dai …
2016
5 اقتباسات
European journal of …
2016
BMC infectious diseases
2014
58 اقتباسات
Clinical infectious diseases …
2013
129 اقتباسات
Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial.
RCT
Clinical infectious diseases …
2013
58 اقتباسات
Indian journal of …
2013
24 اقتباسات
Acta scientiarum polonorum. …
2012
11 اقتباسات
International journal of …
2011
49 اقتباسات
The Journal of …
2010
93 اقتباسات
Journal of the …
2010
11 اقتباسات
Archives of internal …
2009
975 اقتباسات
Clinical journal of …
2008
148 اقتباسات
International journal of …
2002
26 اقتباسات
Manometric study in Kearns-Sayre syndrome.
Case Report
Diseases of the …
2001
7 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
الحد الأعلى: 4,000 IU/day (100 mcg)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| Disease-modifying agents (tolvaptan, etc.) | -- | Positive | -- |
| Probiotics, nutraceuticals | -- | Positive | -- |
| 600-800 IU (DRI) or higher | -- | Positive | -- |
| 400 IU | -- | Negative | 5748 |
| 98% | 26.0 weeks | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 50554 |
أفضل وقت للتناول: With a meal containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
التفاعلات المعروفة
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
الحد الأقصى المسموح به: 4,000 IU/day (100 mcg)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Vitamin D help with Upper Respiratory Tract Infections?
Based on 40 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 40 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Upper Respiratory Tract Infections
Vitamin D لحالات أخرى
References
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