Beta-Glucan لـ Upper Respiratory Tract Infections

Q: Does Beta-Glucan help with Upper Respiratory Tract Infections?

Based on 13 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Beta-Glucan may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).

Q: How much Beta-Glucan should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Beta-Glucan?

Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects (bloating), Allergic reactions in yeast-sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Beta-Glucan and Upper Respiratory Tract Infections?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 13 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

A الأدلة تُظهر تجارب سريرية كبيرة متعددة باستمرار فوائد ملحوظة.

Meta-analysis of 13 randomized controlled trials shows yeast beta-glucan may help reduce the incidence, number of episodes, and duration of upper respiratory tract infections compared to placebo. A 16-week RCT with 162 participants found 25% reduction in symptomatic cold infections.

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الخلاصة

Key Study Findings

Randomized Controlled Trial

The anti-infective effect of β-glucans in children.

Dose: 10 mg مقابل: Placebo Outcome: Body weight التأثير: None None

المجتمع المدروس: None

In Vitro

Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker's …

Dose: 250 mg/d مقابل: None Outcome: oxidative stress markers التأثير: None None

المجتمع المدروس: None

Randomized Controlled Trial 12 weeks Double-blind

β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and …

Dose: None مقابل: Placebo Outcome: Protective Qi status improvement التأثير: None None

المجتمع المدروس: Adults with Protective Qi deficiency

Meta-Analysis

Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in …

Dose: 95% مقابل: placebo Outcome: None التأثير: OR = 0.345 p < 0.001

المجتمع المدروس: healthy subjects

Randomized Controlled Trial n=69

Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A …

Dose: 250 mL/d مقابل: Placebo Outcome: None التأثير: None None

المجتمع المدروس: URTI patients

Randomized Controlled Trial n=132 Double-blind

Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled …

Dose: 250 mL/d مقابل: Placebo Outcome: None التأثير: None p < .05

المجتمع المدروس: URTI patients

Key Statistics

الدراسات

2000

المشاركون

↑

Positive

التقييم

Referenced Papers

The anti-infective effect of β-glucans in children. Review

International journal for … 2024 5 اقتباسات

Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker's yeast beta glucan. Other

Methods (San Diego, … 2023 6 اقتباسات

β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial. RCT

Chinese journal of … 2022 2 اقتباسات

Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review … Meta-Analysis

European journal of … 2021 21 اقتباسات

Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial. RCT

Journal of dietary … 2020 27 اقتباسات

Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial. RCT

Journal of medicinal … 2020 24 اقتباسات

Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects. RCT

Journal of the … 2019 47 اقتباسات

Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. RCT

Nutrients 2019 34 اقتباسات

Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. RCT

Journal of dietary … 2013 99 اقتباسات

Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress. Other

American journal of … 2009 34 اقتباسات

Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. Other

Journal of sports … 2009

Beta-glucan, immune function, and upper respiratory tract infections in athletes. RCT

Medicine and science … 2008 71 اقتباسات

Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. Other

American journal of … 2008 45 اقتباسات

Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. Review

Journal of sports … 2006 94 اقتباسات

Effects of moderate exercise and oat beta-glucan on innate immune function and susceptibility to respiratory infection. Other

American journal of … 2004 107 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 250-500 mg/day
immunesupport:: 250-750 mg/day

الحد الأعلى: No established UL

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
10 mg	--	Positive	--
250 mg/d	--	Positive	--
None	12 weeks	Positive	--
95%	--	Positive	--
250 mL/d	--	Mixed	69
250 mL/d	--	Neutral	132
900 mg	16.0 weeks	Positive	299
367 mg	12.9 weeks	Positive	34

أفضل وقت للتناول: On empty stomach for optimal immune activation

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Generally very well tolerated
⚠ Mild gastrointestinal effects (bloating)
⚠ Allergic reactions in yeast-sensitive individuals

التفاعلات المعروفة

● Immunosuppressant medications (may counteract immunosuppression)
● Generally few known drug interactions

الحد الأقصى المسموح به: No established UL

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Beta-Glucan help with Upper Respiratory Tract Infections?

Based on 13 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Beta-Glucan may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).

How much Beta-Glucan should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Beta-Glucan?

Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects (bloating), Allergic reactions in yeast-sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Beta-Glucan and Upper Respiratory Tract Infections?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 13 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

مكونات أخرى لـ Upper Respiratory Tract Infections

Vitamin D A Zinc A Vitamin C B Echinacea B Andrographis B Garlic B

الخلاصة السريعة

Evidence Strength92%

High confidence

تفصيل الدراسات

RCT (7)Meta (1)Other (5)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Upper Respiratory Tract Infections

اعرف المزيد

References

[1] Katarzyna Wzorek-Łyczko et al.. Int J Vitam Nutr Res. 2024. The anti-infective effect of β-glucans in children. doi:10.1024/0300-9831/a000793 PubMed
[2] Brian K McFarlin et al.. Methods. 2023. Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker's yeast beta glucan. doi:10.1016/j.ymeth.2023.09.006 PubMed
[3] Jun-Rong Wu et al.. Chin J Integr Med. 2022. β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial. doi:10.1007/s11655-021-3444-0 PubMed
[4] Kunxia Zhong et al.. Eur J Nutr. 2021. Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review … doi:10.1007/s00394-021-02566-4 PubMed
[5] Eunice Mah et al.. J Diet Suppl. 2020. Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial. doi:10.1080/19390211.2018.1495676 PubMed
[6] Eunice Mah et al.. J Med Food. 2020. Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial. doi:10.1089/jmf.2019.0076 PubMed
[7] Tanita Dharsono et al.. J Am Coll Nutr. 2019. Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects. doi:10.1080/07315724.2018.1478339 PubMed
[8] Malkanthi Evans et al.. Nutrients. 2019. Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu11122926 PubMed
[9] Brian K McFarlin et al.. J Diet Suppl. 2013. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. doi:10.3109/19390211.2013.820248 PubMed
[10] E Angela Murphy et al.. Am J Physiol Regul Integr Comp Physiol. 2009. Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress. doi:10.1152/ajpregu.00396.2009 PubMed
[11] Shawn Talbott et al.. J Sports Sci Med. 2009. Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. PubMed
[12] David C Nieman et al.. Med Sci Sports Exerc. 2008. Beta-glucan, immune function, and upper respiratory tract infections in athletes. doi:10.1249/MSS.0b013e31817057c2 PubMed
[13] E A Murphy et al.. Am J Physiol Regul Integr Comp Physiol. 2008. Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. doi:10.1152/ajpregu.00562.2007 PubMed
[14] David C Nieman et al.. J Sports Sci. 2006. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. doi:10.1080/02640410500482982 PubMed
[15] J M Davis et al.. Am J Physiol Regul Integr Comp Physiol. 2004. Effects of moderate exercise and oat beta-glucan on innate immune function and susceptibility to respiratory infection. doi:10.1152/ajpregu.00304.2003 PubMed

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