Beta-Glucan 用于 上呼吸道感染
A 证据 多项大型临床试验一致显示出显著的益处。Meta-analysis of 13 randomized controlled trials shows yeast beta-glucan may help reduce the incidence, number of episodes, and duration of upper respiratory tract infections compared to placebo. A 16-week RCT with 162 participants found 25% reduction in symptomatic cold infections.
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A
结论
Meta-analysis of 13 randomized controlled trials shows yeast beta-glucan may help reduce the incidence, number of episodes, and duration of upper respiratory tract infections compared to placebo. A 16-week RCT with 162 participants found 25% reduction in symptomatic cold infections.
Key Study Findings
Randomized Controlled Trial
The anti-infective effect of β-glucans in children.
Dose: 10 mg
vs: Placebo
Outcome: Body weight
效果: None
None
研究人群: None
In Vitro
Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker's …
Dose: 250 mg/d
vs: None
Outcome: oxidative stress markers
效果: None
None
研究人群: None
Randomized Controlled Trial
12 weeks
Double-blind
β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and …
Dose: None
vs: Placebo
Outcome: Protective Qi status improvement
效果: None
None
研究人群: Adults with Protective Qi deficiency
Meta-Analysis
Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in …
Dose: 95%
vs: placebo
Outcome: None
效果: OR = 0.345
p < 0.001
研究人群: healthy subjects
Randomized Controlled Trial
n=69
Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A …
Dose: 250 mL/d
vs: Placebo
Outcome: None
效果: None
None
研究人群: URTI patients
Randomized Controlled Trial
n=132
Double-blind
Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled …
Dose: 250 mL/d
vs: Placebo
Outcome: None
效果: None
p < .05
研究人群: URTI patients
Key Statistics
13
研究数量
2000
受试者
↑
Positive
A
等级
Referenced Papers
International journal for …
2024
5 次引用
Methods (San Diego, …
2023
6 次引用
Chinese journal of …
2022
2 次引用
European journal of …
2021
21 次引用
Journal of dietary …
2020
27 次引用
Journal of medicinal …
2020
24 次引用
Journal of the …
2019
47 次引用
Nutrients
2019
34 次引用
Journal of dietary …
2013
99 次引用
American journal of …
2009
34 次引用
Journal of sports …
2009
Medicine and science …
2008
71 次引用
American journal of …
2008
45 次引用
Journal of sports …
2006
94 次引用
American journal of …
2004
107 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 250-500 mg/day
- immunesupport:
- 250-750 mg/day
上限： No established UL
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 10 mg | -- | Positive | -- |
| 250 mg/d | -- | Positive | -- |
| None | 12 weeks | Positive | -- |
| 95% | -- | Positive | -- |
| 250 mL/d | -- | Mixed | 69 |
| 250 mL/d | -- | Neutral | 132 |
| 900 mg | 16.0 weeks | Positive | 299 |
| 367 mg | 12.9 weeks | Positive | 34 |
最佳服用时间： On empty stomach for optimal immune activation
Safety & Side Effects
已报告的副作用
- ⚠ Generally very well tolerated
- ⚠ Mild gastrointestinal effects (bloating)
- ⚠ Allergic reactions in yeast-sensitive individuals
已知相互作用
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Generally few known drug interactions
可耐受最高摄入量： No established UL
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Beta-Glucan help with 上呼吸道感染?
Based on 13 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Beta-Glucan may support 上呼吸道感染 management. Our evidence grade is A (Strong Evidence).
How much Beta-Glucan should I take for 上呼吸道感染?
Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Beta-Glucan?
Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects (bloating), Allergic reactions in yeast-sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Beta-Glucan and 上呼吸道感染?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 13 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 上呼吸道感染
References
- [1] Katarzyna Wzorek-Łyczko et al.. Int J Vitam Nutr Res. 2024. The anti-infective effect of β-glucans in children. doi:10.1024/0300-9831/a000793 PubMed
- [2] Brian K McFarlin et al.. Methods. 2023. Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker's yeast beta glucan. doi:10.1016/j.ymeth.2023.09.006 PubMed
- [3] Jun-Rong Wu et al.. Chin J Integr Med. 2022. β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial. doi:10.1007/s11655-021-3444-0 PubMed
- [4] Kunxia Zhong et al.. Eur J Nutr. 2021. Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review … doi:10.1007/s00394-021-02566-4 PubMed
- [5] Eunice Mah et al.. J Diet Suppl. 2020. Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial. doi:10.1080/19390211.2018.1495676 PubMed
- [6] Eunice Mah et al.. J Med Food. 2020. Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial. doi:10.1089/jmf.2019.0076 PubMed
- [7] Tanita Dharsono et al.. J Am Coll Nutr. 2019. Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects. doi:10.1080/07315724.2018.1478339 PubMed
- [8] Malkanthi Evans et al.. Nutrients. 2019. Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. doi:10.3390/nu11122926 PubMed
- [9] Brian K McFarlin et al.. J Diet Suppl. 2013. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. doi:10.3109/19390211.2013.820248 PubMed
- [10] E Angela Murphy et al.. Am J Physiol Regul Integr Comp Physiol. 2009. Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress. doi:10.1152/ajpregu.00396.2009 PubMed
- [11] Shawn Talbott et al.. J Sports Sci Med. 2009. Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. PubMed
- [12] David C Nieman et al.. Med Sci Sports Exerc. 2008. Beta-glucan, immune function, and upper respiratory tract infections in athletes. doi:10.1249/MSS.0b013e31817057c2 PubMed
- [13] E A Murphy et al.. Am J Physiol Regul Integr Comp Physiol. 2008. Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. doi:10.1152/ajpregu.00562.2007 PubMed
- [14] David C Nieman et al.. J Sports Sci. 2006. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. doi:10.1080/02640410500482982 PubMed
- [15] J M Davis et al.. Am J Physiol Regul Integr Comp Physiol. 2004. Effects of moderate exercise and oat beta-glucan on innate immune function and susceptibility to respiratory infection. doi:10.1152/ajpregu.00304.2003 PubMed
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