Vitamin D per Upper Respiratory Tract Infections

Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'immunecited.com'; const params = 'ingredient\u003Dvitamin\u002Dd\u0026condition\u003Dupper\u002Drespiratory\u002Dinfections'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

In sintesi

Key Study Findings

Review

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Elite/professional cyclists nutrition review

Systematic Review

Interventions for preventing the progression of autosomal dominant polycystic kidney disease.

Dose: Disease-modifying agents (tolvaptan, etc.) vs: Placebo or standard care Outcome: Kidney disease progression Effetto: None None

Popolazione: Patients with ADPKD

Review

Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …

Dose: Probiotics, nutraceuticals vs: None Outcome: Immune response modulation in COVID-19 Effetto: None None

Popolazione: COVID-19 patients with gut dysbiosis

Review

Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature.

Dose: 600-800 IU (DRI) or higher vs: None Outcome: Skeletal and extra-skeletal health benefits Effetto: None None

Popolazione: General population (guideline comparison)

Meta-Analysis n=5748

High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 …

Dose: 400 IU vs: Placebo Outcome: None Effetto: None None

Popolazione: Healthy adults

Case-Control 26.0 weeks

Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection.

Dose: 98% vs: control Outcome: None Effetto: None None

Popolazione: None

Key Statistics

Studi

30000

Partecipanti

↑

Positive

Grado

Referenced Papers

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. Other

International journal of … 2025 2 citazioni

Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature. Review

Endocrine practice : … 2024 24 citazioni

High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and … Meta-Analysis

Nutrition reviews 2024 9 citazioni

Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections. Review

Journal of translational … 2024 2 citazioni

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 citazioni

Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection. Other

Indian journal of … 2023

Tapinarof for the treatment of psoriasis. Review

Dermatologic therapy 2022 42 citazioni

Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication … Meta-Analysis

Clinical nutrition (Edinburgh, … 2022 17 citazioni

Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. RCT

Medicine and science … 2021 18 citazioni

Vitamin D and upper respiratory tract infections in young active males exposed to cold environments. Other

Annals of agricultural … 2021 3 citazioni

Prenatal vitamin D supplementation and child respiratory health: A systematic review and meta-analysis of randomized controlled trials. Review

The World Allergy … 2020 16 citazioni

Intake of 25-Hydroxyvitamin D3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, … RCT

Nutrients 2020 1 citazioni

Effect of High-Dose Vitamin D Supplementation on Upper Respiratory Tract Infection Symptom Severity in Healthy Children. RCT

The Pediatric infectious … 2019 15 citazioni

Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency. Other

European archives of … 2019 14 citazioni

Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes. Observational

The Journal of … 2019 9 citazioni

Infection Status of Rural Schoolchildren and its Relationship with Vitamin D Concentrations. RCT

Indian journal of … 2019 3 citazioni

Dietary Supplements for Health, Adaptation, and Recovery in Athletes. Review

International journal of … 2018 165 citazioni

Vitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A … RCT

International journal of … 2018 37 citazioni

Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison … RCT

The journal of … 2018 27 citazioni

Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children. RCT

JAMA 2017 131 citazioni

25-Hydroxyvitamin D supplementation and health-service utilization for upper respiratory tract infection in young children. Other

Public health nutrition 2017 6 citazioni

Vitamin D and airway infections: a European perspective. Review

European journal of … 2016 93 citazioni

Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. RCT

American journal of … 2016 45 citazioni

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs. Review

Journal of general … 2016 38 citazioni

The association of residential mold exposure and adenotonsillar hypertrophy in children living in damp environments. Other

International journal of … 2016 22 citazioni

Association between serum vitamin D, retinol and zinc status, and acute respiratory infections in underweight and normal-weight children aged 6-24 … Other

Epidemiology and infection 2016 13 citazioni

[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease]. Other

Zhongguo dang dai … 2016 5 citazioni

The impact of sleeping with reduced glycogen stores on immunity and sleep in triathletes. RCT

European journal of … 2016

Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial. RCT

BMC infectious diseases 2014 58 citazioni

Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Other

Clinical infectious diseases … 2013 129 citazioni

Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. RCT

Clinical infectious diseases … 2013 58 citazioni

Vitamin d deficiency in e.N.T. Patients. Other

Indian journal of … 2013 24 citazioni

New actions for old nutrients. Review

Acta scientiarum polonorum. … 2012 11 citazioni

Vitamin D and tonsil disease--preliminary observations. Other

International journal of … 2011 49 citazioni

Vitamin D, innate immunity and upper respiratory tract infection. Review

The Journal of … 2010 93 citazioni

Cod liver oil, young children, and upper respiratory tract infections. Review

Journal of the … 2010 11 citazioni

Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Other

Archives of internal … 2009 975 citazioni

Clinical and laboratory evaluation of upper respiratory symptoms in elite athletes. Other

Clinical journal of … 2008 148 citazioni

Alarming atrioventricular block and mitral valve prolapse in the Kearns-Sayre syndrome. Case Report

International journal of … 2002 26 citazioni

Manometric study in Kearns-Sayre syndrome. Case Report

Diseases of the … 2001 7 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 600-800 IU/day
immunesupport:: 1,000-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day (under medical supervision)

Limite massimo: 4,000 IU/day (100 mcg)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Mixed	--
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
Probiotics, nutraceuticals	--	Positive	--
600-800 IU (DRI) or higher	--	Positive	--
400 IU	--	Negative	5748
98%	26.0 weeks	Mixed	--
None	--	Positive	--
None	--	Positive	50554

Momento migliore per l'assunzione: With a meal containing fat for better absorption

Safety & Side Effects

Effetti collaterali segnalati

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
⚠ Kidney stones with excessive long-term use
⚠ Constipation
⚠ Metallic taste

Interazioni note

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

Livello di assunzione massimo tollerabile: 4,000 IU/day (100 mcg)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Vitamin D help with Upper Respiratory Tract Infections?

Based on 40 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).

How much Vitamin D should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Upper Respiratory Tract Infections?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 40 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Upper Respiratory Tract Infections

Zinc A Beta-Glucan A Vitamin C B Echinacea B Andrographis B Garlic B

Vitamin D per altre condizioni

Autoimmune Conditions A Immune Aging (Immunosenescence) B

Verdetto rapido

Evidence Strength92%

High confidence

Analisi degli studi

RCT (11)Meta (2)Other (27)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Upper Respiratory Tract Infections

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.