Vitamin C per Upper Respiratory Tract Infections
B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.Research suggests regular vitamin C supplementation may reduce cold duration by approximately 8% in adults and 14% in children. Supplementation at 1g+/day is associated with reduced severity of cold symptoms. Notably, vitamin C started after symptom onset does not appear to be effective.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'immunecited.com';
const params = 'ingredient\u003Dvitamin\u002Dc\u0026condition\u003Dupper\u002Drespiratory\u002Dinfections';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
B
In sintesi
Research suggests regular vitamin C supplementation may reduce cold duration by approximately 8% in adults and 14% in children. Supplementation at 1g+/day is associated with reduced severity of cold symptoms. Notably, vitamin C started after symptom onset does not appear to be effective.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: Elite/professional cyclists nutrition review
Review
Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?
Dose: None
vs: None
Outcome: Micronutrient deficiency management in pediatric IBD
Effetto: None
None
Popolazione: Children with inflammatory bowel disease (review)
Other
Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis.
Dose: 12 circulating micronutrients
vs: Genetic instrument comparison
Outcome: URTI, LRTI, pneumonia risk
Effetto: None
None
Popolazione: Large genetic cohort (MR analysis)
Review
Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …
Dose: Probiotics, nutraceuticals
vs: None
Outcome: Immune response modulation in COVID-19
Effetto: None
None
Popolazione: COVID-19 patients with gut dysbiosis
Randomized Controlled Trial
Zinc and L-Ascorbic Acid Dietary Supplementation Affected Antioxidant Status, Heat Shock Protein 70, and Some …
Dose: None
vs: Basal diet without supplementation
Outcome: Antioxidant status, hematology, growth in broilers
Effetto: None
None
Popolazione: Broiler chickens
Randomized Controlled Trial
n=171
24 weeks
Double-blind
Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged …
Dose: 12.5 billion cfu/d
vs: placebo
Outcome: None
Effetto: or 6
P=0.0300
Popolazione: None
Key Statistics
30
Studi
10000
Partecipanti
↑
Positive
B
Grado
Referenced Papers
Nutrients
2025
4 citazioni
International journal of …
2025
2 citazioni
Journal of translational …
2024
2 citazioni
Frontiers in nutrition
2024
1 citazioni
Biological trace element …
2022
5 citazioni
Beneficial microbes
2021
18 citazioni
European journal of …
2021
Nutrients
2020
75 citazioni
Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children.
Meta-Analysis
European journal of …
2019
54 citazioni
Journal of evidence-based …
2017
134 citazioni
European journal of …
2017
18 citazioni
Zhongguo Zhong yao …
2017
European journal of …
2015
70 citazioni
World journal of …
2015
62 citazioni
Zhongguo Zhong yao …
2014
4 citazioni
Zhongguo Zhong yao …
2013
European journal of …
2012
225 citazioni
The British journal …
2012
40 citazioni
American family physician
2012
Journal of the …
2011
8 citazioni
International journal of …
2008
11 citazioni
American journal of …
2006
51 citazioni
Clinical evidence
2003
Clinical evidence
2003
The British journal …
2002
358 citazioni
Primary care
2002
56 citazioni
American family physician
2002
Canadian journal of …
2001
72 citazioni
Medicine and science …
2000
262 citazioni
Medicine and science …
2000
248 citazioni
Alternative medicine review …
2000
Canadian journal of …
1998
41 citazioni
Journal of applied …
1997
434 citazioni
International journal of …
1997
167 citazioni
Exercise immunology review
1997
27 citazioni
Respiration; international review …
1989
25 citazioni
Scandinavian journal of …
1977
56 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 75-90 mg/day
- acuteillness:
- 1,000-2,000 mg/day
- immunesupport:
- 200-1,000 mg/day
Limite massimo: 2,000 mg/day
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| 12 circulating micronutrients | -- | Mixed | -- |
| Probiotics, nutraceuticals | -- | Positive | -- |
| None | -- | Positive | -- |
| 12.5 billion cfu/d | 24 weeks | Mixed | 171 |
| 45% | 988 weeks | Positive | 26282 |
| None | 13.0 weeks | Mixed | 3135 |
Momento migliore per l'assunzione: With meals; divide doses >500 mg for better absorption
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Gastrointestinal distress (nausea, diarrhea, cramps) at high doses
- ⚠ Increased risk of kidney stones in susceptible individuals
- ⚠ Interference with certain lab tests (glucose, occult blood)
- ⚠ Iron overload risk in hemochromatosis patients
Interazioni note
- ● Enhances non-heme iron absorption (beneficial or harmful depending on iron status)
- ● High doses may reduce effectiveness of certain chemotherapy agents
- ● May interfere with anticoagulant therapy (warfarin) at high doses
- ● Aluminum-containing antacids (increased aluminum absorption)
Livello di assunzione massimo tollerabile: 2,000 mg/day
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Vitamin C help with Upper Respiratory Tract Infections?
Based on 30 studies with 10,000 participants, there is moderate evidence from clinical studies that Vitamin C may support Upper Respiratory Tract Infections management. Our evidence grade is B (Good Evidence).
How much Vitamin C should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 75-90 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin C?
Reported side effects may include Gastrointestinal distress (nausea, diarrhea, cramps) at high doses, Increased risk of kidney stones in susceptible individuals, Interference with certain lab tests (glucose, occult blood), Iron overload risk in hemochromatosis patients. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin C and Upper Respiratory Tract Infections?
We rate the evidence as Grade B (Good Evidence). This rating is based on 30 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Upper Respiratory Tract Infections
Vitamin C per altre condizioni
References
- [1] Tiziana Galeazzi et al.. Nutrients. 2025. Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? doi:10.3390/nu17091425 PubMed
- [2] Patrick B Wilson et al.. Int J Sport Nutr Exerc Metab. 2025. UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. doi:10.1123/ijsnem.2025-0144 PubMed
- [3] Anju Kaushal. J Transl Med. 2024. Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections. doi:10.1186/s12967-024-05587-9 PubMed
- [4] Zhengxiao Wei et al.. Front Nutr. 2024. Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis. doi:10.3389/fnut.2024.1373179 PubMed
- [5] Ahmed Gouda et al.. Biol Trace Elem Res. 2022. Zinc and L-Ascorbic Acid Dietary Supplementation Affected Antioxidant Status, Heat Shock Protein 70, and Some Immunoglobulins in Japanese Quail Under … doi:10.1007/s12011-021-02884-y PubMed
- [6] I Garaiova et al.. Benef Microbes. 2021. Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial. doi:10.3920/BM2020.0185 PubMed
- [7] Philippe Vorilhon et al.. Eur J Clin Pharmacol. 2021. Retraction Note: Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. doi:10.1007/s00228-021-03150-9 PubMed
- [8] Carroll A Reider et al.. Nutrients. 2020. Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. doi:10.3390/nu12061735 PubMed
- [9] Philippe Vorilhon et al.. Eur J Clin Pharmacol. 2019. Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. doi:10.1007/s00228-018-2601-7 PubMed
- [10] Haider Abdul-Lateef Mousa. J Evid Based Complementary Altern Med. 2017. Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies. doi:10.1177/2156587216641831 PubMed
- [11] S E Raposo et al.. Eur J Clin Nutr. 2017. Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study. doi:10.1038/ejcn.2016.261 PubMed
- [12] Li-Zhen Chen et al.. Zhongguo Zhong Yao Za Zhi. 2017. [Clinical features analysis of Qingkailing injection for adolescent patients based on real world HIS]. doi:10.19540/j.cnki.cjcmm.20170705.010 PubMed
- [13] I Garaiova et al.. Eur J Clin Nutr. 2015. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. doi:10.1038/ejcn.2014.174 PubMed
- [14] Omar A Masri et al.. World J Gastroenterol. 2015. Role of vitamins in gastrointestinal diseases. doi:10.3748/wjg.v21.i17.5191 PubMed
- [15] Jian-hong Li et al.. Zhongguo Zhong Yao Za Zhi. 2014. [Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. PubMed
- [16] Zhi-Fei Wang et al.. Zhongguo Zhong Yao Za Zhi. 2013. [Analysis of actual effects of combining xiyanping injection with vitamin C injection in treatment of upper respiratory tract infection]. PubMed
- [17] Nils Hovdenak et al.. Eur J Obstet Gynecol Reprod Biol. 2012. Influence of mineral and vitamin supplements on pregnancy outcome. doi:10.1016/j.ejogrb.2012.06.020 PubMed
- [18] Denise C Hunter et al.. Br J Nutr. 2012. Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C … doi:10.1017/S0007114511006659 PubMed
- [19] Julia Fashner et al.. Am Fam Physician. 2012. Treatment of the common cold in children and adults. PubMed
- [20] Elinor Fondell et al.. J Am Coll Nutr. 2011. Dietary intake and supplement use of vitamins C and E and upper respiratory tract infection. doi:10.1080/07315724.2011.10719967 PubMed
- [21] Andres E Carrillo et al.. Int J Sports Physiol Perform. 2008. Vitamin C supplementation and salivary immune function following exercise-heat stress. doi:10.1123/ijspp.3.4.516 PubMed
- [22] Roxane R Carr et al.. Am J Health Syst Pharm. 2006. Complementary and alternative medicine for upper-respiratory-tract infection in children. doi:10.2146/ajhp040613 PubMed
- [23] Chris Del Mar et al.. Clin Evid. 2003. Upper respiratory tract infection. PubMed
- [24] Chris Del Mar et al.. Clin Evid. 2003. Upper respiratory tract infection. PubMed
- [25] Philip C Calder et al.. Br J Nutr. 2002. The immune system: a target for functional foods? doi:10.1079/BJN2002682 PubMed
- [26] Raja Jaber. Prim Care. 2002. Respiratory and allergic diseases: from upper respiratory tract infections to asthma. doi:10.1016/s0095-4543(01)00008-2 PubMed
- [27] Chris B Del Mar et al.. Am Fam Physician. 2002. Upper respiratory tract infection. PubMed
- [28] D C Nieman. Can J Appl Physiol. 2001. Exercise immunology: nutritional countermeasures. doi:10.1139/h2001-041 PubMed
- [29] D C Nieman. Med Sci Sports Exerc. 2000. Is infection risk linked to exercise workload? doi:10.1097/00005768-200007001-00005 PubMed
- [30] L T Mackinnon. Med Sci Sports Exerc. 2000. Chronic exercise training effects on immune function. doi:10.1097/00005768-200007001-00001 PubMed
- [31] S M Thornhill et al.. Altern Med Rev. 2000. Natural treatment of perennial allergic rhinitis. PubMed
- [32] D C Nieman. Can J Physiol Pharmacol. 1998. Exercise and resistance to infection. doi:10.1139/cjpp-76-5-573 PubMed
- [33] D C Nieman. J Appl Physiol (1985). 1997. Immune response to heavy exertion. doi:10.1152/jappl.1997.82.5.1385 PubMed
- [34] E M Peters. Int J Sports Med. 1997. Exercise, immunology and upper respiratory tract infections. doi:10.1055/s-2007-972702 PubMed
- [35] E M Peters-Futre. Exerc Immunol Rev. 1997. Vitamin C, neutrophil function, and upper respiratory tract infection risk in distance runners: the missing link. PubMed
- [36] C Bucca et al.. Respiration. 1989. Effect of ascorbic acid on increased bronchial responsiveness during upper airway infection. doi:10.1159/000195737 PubMed
- [37] J Ludvigsson et al.. Scand J Infect Dis. 1977. Vitamin C as a preventive medicine against common colds in children. doi:10.3109/inf.1977.9.issue-2.07 PubMed
Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.