Vitamin D para Upper Respiratory Tract Infections
A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
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A
Conclusão
Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: Elite/professional cyclists nutrition review
Systematic Review
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Dose: Disease-modifying agents (tolvaptan, etc.)
vs: Placebo or standard care
Outcome: Kidney disease progression
Efeito: None
None
População: Patients with ADPKD
Review
Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …
Dose: Probiotics, nutraceuticals
vs: None
Outcome: Immune response modulation in COVID-19
Efeito: None
None
População: COVID-19 patients with gut dysbiosis
Review
Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature.
Dose: 600-800 IU (DRI) or higher
vs: None
Outcome: Skeletal and extra-skeletal health benefits
Efeito: None
None
População: General population (guideline comparison)
Meta-Analysis
n=5748
High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 …
Dose: 400 IU
vs: Placebo
Outcome: None
Efeito: None
None
População: Healthy adults
Case-Control
26.0 weeks
Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection.
Dose: 98%
vs: control
Outcome: None
Efeito: None
None
População: None
Key Statistics
40
Estudos
30000
Participantes
↑
Positive
A
Nota
Referenced Papers
International journal of …
2025
2 citações
Endocrine practice : …
2024
24 citações
Nutrition reviews
2024
9 citações
Journal of translational …
2024
2 citações
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 citações
Indian journal of …
2023
Dermatologic therapy
2022
42 citações
Clinical nutrition (Edinburgh, …
2022
17 citações
Medicine and science …
2021
18 citações
Vitamin D and upper respiratory tract infections in young active males exposed to cold environments.
Other
Annals of agricultural …
2021
3 citações
The World Allergy …
2020
16 citações
Nutrients
2020
1 citações
The Pediatric infectious …
2019
15 citações
European archives of …
2019
14 citações
Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes.
Observational
The Journal of …
2019
9 citações
Indian journal of …
2019
3 citações
International journal of …
2018
165 citações
International journal of …
2018
37 citações
The journal of …
2018
27 citações
JAMA
2017
131 citações
Public health nutrition
2017
6 citações
European journal of …
2016
93 citações
American journal of …
2016
45 citações
Journal of general …
2016
38 citações
International journal of …
2016
22 citações
Epidemiology and infection
2016
13 citações
[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease].
Other
Zhongguo dang dai …
2016
5 citações
European journal of …
2016
BMC infectious diseases
2014
58 citações
Clinical infectious diseases …
2013
129 citações
Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial.
RCT
Clinical infectious diseases …
2013
58 citações
Indian journal of …
2013
24 citações
Acta scientiarum polonorum. …
2012
11 citações
International journal of …
2011
49 citações
The Journal of …
2010
93 citações
Journal of the …
2010
11 citações
Archives of internal …
2009
975 citações
Clinical journal of …
2008
148 citações
International journal of …
2002
26 citações
Manometric study in Kearns-Sayre syndrome.
Case Report
Diseases of the …
2001
7 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Limite superior: 4,000 IU/day (100 mcg)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Disease-modifying agents (tolvaptan, etc.) | -- | Positive | -- |
| Probiotics, nutraceuticals | -- | Positive | -- |
| 600-800 IU (DRI) or higher | -- | Positive | -- |
| 400 IU | -- | Negative | 5748 |
| 98% | 26.0 weeks | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 50554 |
Melhor horário: With a meal containing fat for better absorption
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Interações Conhecidas
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Ingestão máxima tolerável: 4,000 IU/day (100 mcg)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Vitamin D help with Upper Respiratory Tract Infections?
Based on 40 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 40 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Upper Respiratory Tract Infections
Vitamin D para outras condições
References
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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.