Andrographis para Upper Respiratory Tract Infections

Q: Does Andrographis help with Upper Respiratory Tract Infections?

Based on 7 studies with 800 participants, there is moderate evidence from clinical studies that Andrographis may support Upper Respiratory Tract Infections management. Our evidence grade is B (Good Evidence).

Q: How much Andrographis should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 400 mg 3x/day for up to 7 days. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Andrographis?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Fatigue, Allergic reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Andrographis and Upper Respiratory Tract Infections?

We rate the evidence as Grade B (Good Evidence). This rating is based on 7 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.

Multiple randomized controlled trials and Cochrane-reviewed meta-analyses support andrographis for reducing the severity and duration of upper respiratory symptoms. One of the most evidence-backed herbal supplements for acute respiratory infections.

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Conclusão

Key Study Findings

Randomized Controlled Trial n=331 1.0 weeks Double-blind

Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common …

Dose: 200 mg/day vs: placebo Outcome: URTI symptom severity Efeito: None p = 0.034

População: Participants with uncomplicated URTI

Review

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead …

Dose: None vs: None Outcome: URTI symptom severity Efeito: None None

População: COVID-19/URTI patients

Review

Plant-Based Support of Respiratory Health during Viral Outbreaks.

Dose: None vs: None Outcome: None Efeito: None None

População: None

Other n=179

Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study.

Dose: 60 mg vs: placebo Outcome: None Efeito: None p = 0.0053

População: None

Meta-Analysis n=1000

Safety of Andrographis paniculata: A systematic review and meta-analysis.

Dose: 95% vs: control Outcome: None Efeito: None None

População: upper respiratory tract infection

Other

In vitro anti-biofilm activity of 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata against Pseudomonas aeruginosa.

Dose: 6 μg/mL vs: Control group Outcome: None Efeito: None None

População: None

Key Statistics

Estudos

800

Participantes

↑

Positive

Nota

Referenced Papers

Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common cold) - A phase III, … RCT

Complementary therapies in … 2023 6 citações

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery. Review

Molecules (Basel, Switzerland) 2022 80 citações

Plant-Based Support of Respiratory Health during Viral Outbreaks. Other

Journal of agricultural … 2022 9 citações

Safety of Andrographis paniculata: A systematic review and meta-analysis. Meta-Analysis

Pharmacoepidemiology and drug … 2021 32 citações

Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study. Other

Journal of traditional … 2021 9 citações

In vitro anti-biofilm activity of 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata against Pseudomonas aeruginosa. Other

Brazilian journal of … 2020 45 citações

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Other

Cell death & … 2019 160 citações

A review for the neuroprotective effects of andrographolide in the central nervous system. Review

Biomedicine & pharmacotherapy … 2019 103 citações

A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory … RCT

Phytomedicine : international … 2010 107 citações

Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Review

Alternative medicine review … 2007 163 citações

Complementary and alternative medicine for upper-respiratory-tract infection in children. Review

American journal of … 2006 51 citações

Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Systematic Review

Planta medica 2004 262 citações

Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. Systematic Review

Journal of clinical … 2004 157 citações

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 citações

Undetectable anti-bacterial activity of Andrographis paniculata (Burma) wall. ex ness. RCT

Journal of the … 1990

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

acute:: 400 mg 3x/day for up to 7 days
general:: 200 mg standardized extract (30% andrographolides) 2x/day

Limite superior: No established UL; short-term use (<14 days)

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
200 mg/day	1.0 weeks	Positive	331
None	--	Positive	--
None	--	Mixed	--
60 mg	--	Positive	179
95%	--	Neutral	1000
6 μg/mL	--	Positive	--
None	--	Mixed	--
18 G	4.0 weeks	Mixed	--

Melhor horário: At first sign of symptoms; with meals

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Headache
⚠ Fatigue
⚠ Allergic reactions (rare)
⚠ Potential anti-fertility effects (high doses in animal studies)

Interações Conhecidas

● Anticoagulant and antiplatelet drugs (may increase bleeding risk)
● Antihypertensive medications (additive blood pressure lowering)
● Immunosuppressant medications (may counteract immunosuppression)

Ingestão máxima tolerável: No established UL; short-term use (<14 days)

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Andrographis help with Upper Respiratory Tract Infections?

Based on 7 studies with 800 participants, there is moderate evidence from clinical studies that Andrographis may support Upper Respiratory Tract Infections management. Our evidence grade is B (Good Evidence).

How much Andrographis should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 400 mg 3x/day for up to 7 days. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Andrographis?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Fatigue, Allergic reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Andrographis and Upper Respiratory Tract Infections?

We rate the evidence as Grade B (Good Evidence). This rating is based on 7 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Upper Respiratory Tract Infections

Vitamin D A Zinc A Beta-Glucan A Vitamin C B Echinacea B Garlic B

Veredito Rápido

Evidence Strength72%

High confidence

Detalhamento dos Estudos

RCT (3)Meta (1)Other (3)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Upper Respiratory Tract Infections

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.