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안드로그라피스 관련 상기도 감염

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Multiple randomized controlled trials and Cochrane-reviewed meta-analyses support andrographis for reducing the severity and duration of upper respiratory symptoms. One of the most evidence-backed herbal supplements for acute respiratory infections.

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결론

Multiple randomized controlled trials and Cochrane-reviewed meta-analyses support andrographis for reducing the severity and duration of upper respiratory symptoms. One of the most evidence-backed herbal supplements for acute respiratory infections.

Key Study Findings

Randomized Controlled Trial n=331 1.0 weeks Double-blind
Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common …
Dose: 200 mg/day vs: placebo Outcome: URTI symptom severity 효과: None p = 0.034

대상 집단: Participants with uncomplicated URTI

Review
A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead …
Dose: None vs: None Outcome: URTI symptom severity 효과: None None

대상 집단: COVID-19/URTI patients

Review
Plant-Based Support of Respiratory Health during Viral Outbreaks.
Dose: None vs: None Outcome: None 효과: None None

대상 집단: None

Other n=179
Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study.
Dose: 60 mg vs: placebo Outcome: None 효과: None p = 0.0053

대상 집단: None

Meta-Analysis n=1000
Safety of Andrographis paniculata: A systematic review and meta-analysis.
Dose: 95% vs: control Outcome: None 효과: None None

대상 집단: upper respiratory tract infection

Other
In vitro anti-biofilm activity of 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata against Pseudomonas aeruginosa.
Dose: 6 μg/mL vs: Control group Outcome: None 효과: None None

대상 집단: None

Key Statistics

7

연구

800

참여자

Positive

B

등급

Referenced Papers

Journal of agricultural … 2022 9 인용
Pharmacoepidemiology and drug … 2021 32 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

acute:
400 mg 3x/day for up to 7 days
general:
200 mg standardized extract (30% andrographolides) 2x/day

상한량: No established UL; short-term use (<14 days)

연구에서 사용된 용량

용량 기간 효과 N
200 mg/day 1.0 weeks Positive 331
None -- Positive --
None -- Mixed --
60 mg -- Positive 179
95% -- Neutral 1000
6 μg/mL -- Positive --
None -- Mixed --
18 G 4.0 weeks Mixed --

권장 복용 시간: At first sign of symptoms; with meals

Safety & Side Effects

보고된 부작용

  • Gastrointestinal discomfort (nausea, diarrhea)
  • Headache
  • Fatigue
  • Allergic reactions (rare)
  • Potential anti-fertility effects (high doses in animal studies)

알려진 상호작용

  • Anticoagulant and antiplatelet drugs (may increase bleeding risk)
  • Antihypertensive medications (additive blood pressure lowering)
  • Immunosuppressant medications (may counteract immunosuppression)

일일 최대 섭취 허용량: No established UL; short-term use (<14 days)

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does 안드로그라피스 help with 상기도 감염?
Based on 7 studies with 800 participants, there is moderate evidence from clinical studies that 안드로그라피스 may support 상기도 감염 management. Our evidence grade is B (Good Evidence).
How much 안드로그라피스 should I take for 상기도 감염?
Studies have used various dosages. A commonly studied range is 400 mg 3x/day for up to 7 days. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of 안드로그라피스?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Fatigue, Allergic reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for 안드로그라피스 and 상기도 감염?
We rate the evidence as Grade B (Good Evidence). This rating is based on 7 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.

References

  1. [1] Jeffrey Pradeep Raj et al.. Complement Ther Med. 2023. Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common cold) - A phase III, … doi:10.1016/j.ctim.2023.102934 PubMed
  2. [2] Aekkhaluck Intharuksa et al.. Molecules. 2022. A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery. doi:10.3390/molecules27144479 PubMed
  3. [3] Thirumurugan Rathinasabapathy et al.. J Agric Food Chem. 2022. Plant-Based Support of Respiratory Health during Viral Outbreaks. doi:10.1021/acs.jafc.1c06227 PubMed
  4. [4] Wiwan Worakunphanich et al.. Pharmacoepidemiol Drug Saf. 2021. Safety of Andrographis paniculata: A systematic review and meta-analysis. doi:10.1002/pds.5190 PubMed
  5. [5] Mikayel Narimanyan et al.. J Tradit Complement Med. 2021. Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study. doi:10.1016/j.jtcme.2021.06.001 PubMed
  6. [6] Moumita Majumdar et al.. Braz J Microbiol. 2020. In vitro anti-biofilm activity of 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata against Pseudomonas aeruginosa. doi:10.1007/s42770-019-00169-0 PubMed
  7. [7] Jian Gao et al.. Cell Death Dis. 2019. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. doi:10.1038/s41419-019-2195-8 PubMed
  8. [8] Jiashu Lu et al.. Biomed Pharmacother. 2019. A review for the neuroprotective effects of andrographolide in the central nervous system. doi:10.1016/j.biopha.2019.109078 PubMed
  9. [9] R C Saxena et al.. Phytomedicine. 2010. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory … doi:10.1016/j.phymed.2009.12.001 PubMed
  10. [10] Mario Roxas et al.. Altern Med Rev. 2007. Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. PubMed
  11. [11] Roxane R Carr et al.. Am J Health Syst Pharm. 2006. Complementary and alternative medicine for upper-respiratory-tract infection in children. doi:10.2146/ajhp040613 PubMed
  12. [12] Joanna Thompson Coon et al.. Planta Med. 2004. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. doi:10.1055/s-2004-818938 PubMed
  13. [13] N Poolsup et al.. J Clin Pharm Ther. 2004. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. doi:10.1046/j.1365-2710.2003.00534.x PubMed
  14. [14] Raja Jaber. Prim Care. 2002. Respiratory and allergic diseases: from upper respiratory tract infections to asthma. doi:10.1016/s0095-4543(01)00008-2 PubMed
  15. [15] A Leelarasamee et al.. J Med Assoc Thai. 1990. Undetectable anti-bacterial activity of Andrographis paniculata (Burma) wall. ex ness. PubMed

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