Vitamin D para Upper Respiratory Tract Infections
A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
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A
Conclusión
Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Elite/professional cyclists nutrition review
Systematic Review
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Dose: Disease-modifying agents (tolvaptan, etc.)
vs: Placebo or standard care
Outcome: Kidney disease progression
Efecto: None
None
Población: Patients with ADPKD
Review
Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …
Dose: Probiotics, nutraceuticals
vs: None
Outcome: Immune response modulation in COVID-19
Efecto: None
None
Población: COVID-19 patients with gut dysbiosis
Review
Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature.
Dose: 600-800 IU (DRI) or higher
vs: None
Outcome: Skeletal and extra-skeletal health benefits
Efecto: None
None
Población: General population (guideline comparison)
Meta-Analysis
n=5748
High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 …
Dose: 400 IU
vs: Placebo
Outcome: None
Efecto: None
None
Población: Healthy adults
Case-Control
26.0 weeks
Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection.
Dose: 98%
vs: control
Outcome: None
Efecto: None
None
Población: None
Key Statistics
40
Estudios
30000
Participantes
↑
Positive
A
Calificación
Referenced Papers
International journal of …
2025
2 citas
Endocrine practice : …
2024
24 citas
Nutrition reviews
2024
9 citas
Journal of translational …
2024
2 citas
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 citas
Indian journal of …
2023
Dermatologic therapy
2022
42 citas
Clinical nutrition (Edinburgh, …
2022
17 citas
Medicine and science …
2021
18 citas
Vitamin D and upper respiratory tract infections in young active males exposed to cold environments.
Other
Annals of agricultural …
2021
3 citas
The World Allergy …
2020
16 citas
Nutrients
2020
1 citas
The Pediatric infectious …
2019
15 citas
European archives of …
2019
14 citas
Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes.
Observational
The Journal of …
2019
9 citas
Indian journal of …
2019
3 citas
International journal of …
2018
165 citas
International journal of …
2018
37 citas
The journal of …
2018
27 citas
JAMA
2017
131 citas
Public health nutrition
2017
6 citas
European journal of …
2016
93 citas
American journal of …
2016
45 citas
Journal of general …
2016
38 citas
International journal of …
2016
22 citas
Epidemiology and infection
2016
13 citas
[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease].
Other
Zhongguo dang dai …
2016
5 citas
European journal of …
2016
BMC infectious diseases
2014
58 citas
Clinical infectious diseases …
2013
129 citas
Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial.
RCT
Clinical infectious diseases …
2013
58 citas
Indian journal of …
2013
24 citas
Acta scientiarum polonorum. …
2012
11 citas
International journal of …
2011
49 citas
The Journal of …
2010
93 citas
Journal of the …
2010
11 citas
Archives of internal …
2009
975 citas
Clinical journal of …
2008
148 citas
International journal of …
2002
26 citas
Manometric study in Kearns-Sayre syndrome.
Case Report
Diseases of the …
2001
7 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Límite superior: 4,000 IU/day (100 mcg)
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Disease-modifying agents (tolvaptan, etc.) | -- | Positive | -- |
| Probiotics, nutraceuticals | -- | Positive | -- |
| 600-800 IU (DRI) or higher | -- | Positive | -- |
| 400 IU | -- | Negative | 5748 |
| 98% | 26.0 weeks | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 50554 |
Mejor momento para tomar: With a meal containing fat for better absorption
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Interacciones conocidas
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Ingesta máxima tolerable: 4,000 IU/day (100 mcg)
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Vitamin D help with Upper Respiratory Tract Infections?
Based on 40 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 40 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Upper Respiratory Tract Infections
Vitamin D para otras condiciones
References
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Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.