Zinc para Upper Respiratory Tract Infections
A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
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A
Conclusión
Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
Key Study Findings
Observational Study
n=107
Open-label
Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory …
Dose: tokishakuyakusan, zinc sulfate, methylcobalamin
vs: medication alone
Outcome: olfactory function improvement via T&T olfactometry
Efecto: OR=4.96
p=0.009
Población: patients with post-viral olfactory dysfunction (non-COVID)
Review
Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Elite/professional cyclists nutrition review
Meta-Analysis
Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents …
Dose: Various oral nutritional supplements
vs: Standard diet or placebo
Outcome: Health outcomes and nutritional biomarkers
Efecto: None
None
Población: Children/adolescents with undernutrition
Controlled Clinical Trial
n=120
5 weeks
Single-blind
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, …
Dose: 20 or 30 days treatment
vs: Standard treatment only (nasal aerosol)
Outcome: Otoscopy, impedance, fibroscopy, pure auditory test
Efecto: None
None
Población: Children with otitis media
Review
Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases …
Dose: 31 μg
vs: None
Outcome: None
Efecto: None
None
Población: respiratory disease
Key Statistics
15
Estudios
1500
Participantes
↑
Positive
A
Calificación
Referenced Papers
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2026
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1 citas
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163 citas
WITHDRAWN: Zinc for the common cold.
Systematic Review
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24 citas
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51 citas
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74 citas
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2003
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2003
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56 citas
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Systematic Review
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 8-11 mg/day
- coldtreatment:
- 75-100 mg/day elemental zinc (lozenges, within 24h of onset, up to 2 weeks)
- immunesupport:
- 15-30 mg/day
Límite superior: 40 mg/day (long-term)
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| tokishakuyakusan, zinc sulfate, methylcobalamin | -- | Positive | 107 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Various oral nutritional supplements | -- | Positive | -- |
| 20 or 30 days treatment | 5 weeks | Positive | 120 |
| 31 μg | -- | Neutral | -- |
| 94.57% | -- | Mixed | -- |
| None | -- | Mixed | 387 |
Mejor momento para tomar: Lozenges: dissolve slowly in mouth every 2-3h at cold onset; Supplements: with food to minimize nausea
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Nausea and vomiting (especially on an empty stomach)
- ⚠ Metallic taste in the mouth
- ⚠ Copper depletion with chronic high-dose use (>40 mg/day)
- ⚠ Headache and diarrhea
Interacciones conocidas
- ● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
- ● Iron supplements (mutual absorption interference when taken together)
Ingesta máxima tolerable: 40 mg/day (long-term)
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Zinc help with Upper Respiratory Tract Infections?
Based on 15 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use (>40 mg/day), Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Upper Respiratory Tract Infections
References
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Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.