Zinc pour Upper Respiratory Tract Infections
A Preuves Plusieurs grands essais cliniques montrent de manière constante des bénéfices significatifs.Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
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A
En conclusion
Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
Key Study Findings
Observational Study
n=107
Open-label
Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory …
Dose: tokishakuyakusan, zinc sulfate, methylcobalamin
vs: medication alone
Outcome: olfactory function improvement via T&T olfactometry
Effet: OR=4.96
p=0.009
Population: patients with post-viral olfactory dysfunction (non-COVID)
Review
Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a …
Dose: None
vs: None
Outcome: None
Effet: None
None
Population: None
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
Effet: None
None
Population: Elite/professional cyclists nutrition review
Meta-Analysis
Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents …
Dose: Various oral nutritional supplements
vs: Standard diet or placebo
Outcome: Health outcomes and nutritional biomarkers
Effet: None
None
Population: Children/adolescents with undernutrition
Controlled Clinical Trial
n=120
5 weeks
Single-blind
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, …
Dose: 20 or 30 days treatment
vs: Standard treatment only (nasal aerosol)
Outcome: Otoscopy, impedance, fibroscopy, pure auditory test
Effet: None
None
Population: Children with otitis media
Review
Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases …
Dose: 31 μg
vs: None
Outcome: None
Effet: None
None
Population: respiratory disease
Key Statistics
15
Études
1500
Participants
↑
Positive
A
Note
Referenced Papers
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2026
International journal of …
2025
2 citations
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2017
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2015
414 citations
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2015
113 citations
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2013
33 citations
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40 citations
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11 citations
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49 citations
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12 citations
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2011
11 citations
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2010
17 citations
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2009
1 citations
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2007
163 citations
WITHDRAWN: Zinc for the common cold.
Systematic Review
The Cochrane database …
2007
24 citations
American journal of …
2006
51 citations
Journal of the …
2004
74 citations
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2003
Clinical evidence
2003
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2002
56 citations
American family physician
2002
Canadian journal of …
2001
72 citations
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2001
8 citations
Zinc for the common cold.
Systematic Review
The Cochrane database …
2000
294 citations
European journal of …
1996
54 citations
Nederlands tijdschrift voor …
1991
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14 citations
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15 citations
Southern medical journal
1978
3 citations
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 8-11 mg/day
- coldtreatment:
- 75-100 mg/day elemental zinc (lozenges, within 24h of onset, up to 2 weeks)
- immunesupport:
- 15-30 mg/day
Limite supérieure : 40 mg/day (long-term)
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| tokishakuyakusan, zinc sulfate, methylcobalamin | -- | Positive | 107 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Various oral nutritional supplements | -- | Positive | -- |
| 20 or 30 days treatment | 5 weeks | Positive | 120 |
| 31 μg | -- | Neutral | -- |
| 94.57% | -- | Mixed | -- |
| None | -- | Mixed | 387 |
Moment optimal de prise : Lozenges: dissolve slowly in mouth every 2-3h at cold onset; Supplements: with food to minimize nausea
Safety & Side Effects
Effets indésirables signalés
- ⚠ Nausea and vomiting (especially on an empty stomach)
- ⚠ Metallic taste in the mouth
- ⚠ Copper depletion with chronic high-dose use (>40 mg/day)
- ⚠ Headache and diarrhea
Interactions connues
- ● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
- ● Iron supplements (mutual absorption interference when taken together)
Apport maximal tolérable : 40 mg/day (long-term)
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Zinc help with Upper Respiratory Tract Infections?
Based on 15 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use (>40 mg/day), Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
Autres ingrédients pour Upper Respiratory Tract Infections
References
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